Loading...
Please wait, while we are loading the content...
Similar Documents
Neuroprotection by R(−)-deprenyl and N-2-hexyl-N-methylpropargylamine on DSP-4, a neurotoxin, induced degeneration of noradrenergic neurons in the rat locus coeruleus
| Content Provider | Semantic Scholar |
|---|---|
| Author | Zhang, Xiaohong Zuo, Dong-Mei Yu, Peter H. |
| Copyright Year | 1995 |
| Abstract | N-(2-Chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) is a neurotoxin and capable of selectively depleting noradrenergic axons and subsequently causing lesions of locus coeruleus (LC) noradrenergic neurons in the rat. R(-)-deprenyl and N-(2-hexyl)-N-methylpropargylamine (2-HxMP) have been previously shown to be quite effective in protecting NA nerve fibers in different brain tissues against DSP-4. The present report reveals the neuroprotective effect of these drugs on the LC noradrenergic cell bodies using a histochemical method. Neurons were quantitatively assessed using Nissl-stained sections. DSP-4 induced a 34% loss of LC perikarya neurons 3 months after a single systemic administration in comparison to control animals. Approximately 90% and 88% of neurons in the same regions survived against DSP-4 induced insult following multiple injections of R(-)-deprenyl and 2-HxMP, respectively. The neuroprotective effect towards the LC neurons against DSP-4 is probably due to prevention of retrograde degeneration of NA axons. |
| Starting Page | 45 |
| Ending Page | 48 |
| Page Count | 4 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0304-3940(95)11278-5 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0304394095112785 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0304394095112785?dgcid=api_sd_search-api-endpoint |
| PubMed reference number | 7540268 |
| Alternate Webpage(s) | https://doi.org/10.1016/0304-3940%2895%2911278-5 |
| Journal | Medline |
| Volume Number | 186 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
