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Sex differences are more than just hormonal
| Content Provider | Semantic Scholar |
|---|---|
| Author | Stapley, Linsey |
| Copyright Year | 2001 |
| Abstract | A wide selection of studies showing that men and women differ on more than just hormonal levels have been detailed in a report by the US Institute of Medicine that recommends researchers to reconsider how they carry out medical research.Differences between the sexes occur on almost every level, from the basic genetic codes to cellular mechanisms, immune system and organ functioning, and, of course, hormones. From studies on the genetically determined functioning of cells, research has shown that many of the genes on the X and Y chromosomes previously thought to be ‘junk’ genes appear to have biologically important functions that are distributed differently between the sexes. Although the significance of all of these differences are not fully understood, they could help explain why men and women appear to experience differences in, for example, autoimmune disease, brain functioning or even life span.Because such differences are likely to also appear in the response of men and women to drugs or therapies, for example in terms of drug response, mode of entry into cells, or drug metabolism, the report urges researchers to include sex differences at all stages of clinical trials. LS |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S1043-2760(01)00419-2 |
| Volume Number | 12 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S1043276001004192 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S1043276001004192?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/S1043-2760%2801%2900419-2 |
| Journal | Trends in Endocrinology & Metabolism |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
