NDLI: Cellular Integration of Thyrocytes Folliculogenesis : A Perspective for Regeneration and Engineering and Thyroid Thyroid Tissue

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Cellular Integration of Thyrocytes Folliculogenesis : A Perspective for Regeneration and Engineering and Thyroid Thyroid Tissue

Content Provider	Semantic Scholar
Author	Koike, Norimasa
Copyright Year	2006
Abstract	THYROID gland consists of many spheroid structures called thyroid follicles. Each follicle, an essential structural and functional unit of the thyroid, is supported by interfollicular extracellular matrix (ECM) and capillary network (Fig. 1, A). Thyrocytes (follicular epithelial cells) of the follicle are the main component cell type. They show specific structural polarity: the apical pole with numerous microvilli faces the follicle lumen, and the basal side with basal lamina confronts ECM (Fig. 1, B). This unique structural characteristic, found in no other endocrine organs, gives rise to thyroid hormone biosynthesis and to its release in a basal-apical (follicle lumen)-basal direction [1-4] (Fig. 1, B). Monolayer and floating culture systems, developed in the 1950s, have been widely used to research on the proliferation and differentiation of thyrocytes [5]. Although these conventional in vitro cultures have facilitated thyroid biology, they have one drawback in that they cannot satisfactorily provide thyrocytes with physiological cellular integration [6, 7] (Fig, 1, C). Three-dimensional (3-D) collagen gel culture system can, in contrast, easily and stably furnish the cells with normal and desired cellular polarity [6, 7] (Fig. 1, B). This culture method therefore is better suited to the study of the biological behavior of thyrocytes in a physiological microenvironment [8, 9]. Despite its cell-specific in vivo capability of integration, little attention has been
File Format	PDF HTM / HTML
Alternate Webpage(s)	https://www.jstage.jst.go.jp/article/endocrj1993/48/4/48_4_407/_pdf/-char/en
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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