NDLI: Nitrogen catabolite repression in a glutamate auxotroph of Saccharomyces cerevisiae.

Content Provider	Semantic Scholar
Author	Kang, L. Keeler, Marilyn L. Dunlop, P. C. Roon, Robert J.
Copyright Year	1982
Abstract	The biosynthesis of asparaginase II in Saccharomyces cerevisiae is subject to nitrogen catabolite repression. In the present study we examined the physiological effects of glutamate auxotrophy on cellular metabolism and on the nitrogen catabolite repression of asparaginase II. Glutamate auxotrophic cells, incubated without a glutamate supplement, had a diminished internal pool of alpha-ketoglutarate and a concomitant inability to equilibrate ammonium ion with alpha-amino nitrogen. In the glutamate auxotroph, asparaginase II biosynthesis exhibited a decreased sensitivity to nitrogen catabolite repression by ammonium ion but normal sensitivity to nitrogen catabolite repression by all amino acids tested.
Starting Page	29
Ending Page	35
Page Count	7
File Format	PDF HTM / HTML
DOI	10.1128/jb.151.1.29-35.1982
PubMed reference number	6123500
Journal	Medline
Volume Number	151
Issue Number	1
Alternate Webpage(s)	http://jb.asm.org/content/151/1/29.full.pdf
Alternate Webpage(s)	https://doi.org/10.1128/jb.151.1.29-35.1982
Journal	Journal of bacteriology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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