NDLI: Platelet aggregation in aortic and coronary venous blood in patients with and without coronary disease. 3. Role of tachycardia stress and propranolol.

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Platelet aggregation in aortic and coronary venous blood in patients with and without coronary disease. 3. Role of tachycardia stress and propranolol.

Content Provider	Semantic Scholar
Author	Mehta, Jayesh Mehta, Paulette Pepine, Carl J.
Copyright Year	1978
Abstract	We studied 16 patients with coronary artery disease (CAD) to evaluate platelet aggregation in blood samples withdrawn simultaneously from the aorta and coronary sinus. At rest, mean platelet aggregation in coronary venous blood was significantly lower than that in aortic blood. Platelet counts in coronary venous blood were also lower than in the aortic blood in each of the six CAD patients in whom counts were done. Platelet aggregation was lower in seven patients who were taking propranolol than in the remaining nine who were not taking propranolol. During tachycardia stress, platelet aggregation increased in all patients, but the magnitude of increase was greater in patients not taking propranolol. In four other patients without CAD, platelet aggregation and counts were also studied in the same fashion and were similar in both the aortic and coronary venous blood. These data suggest that in certain CAD patients, platelet consumption or destruction within atherosclerotic vasculature may occur. Propranolol may reduce platelet aggregation at rest and modify excessive aggregation during tachycardia stress in certain CAD patients.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/58/5/881.full.pdf?download=true
Alternate Webpage(s)	http://circ.ahajournals.org/content/circulationaha/58/5/881.full.pdf
PubMed reference number	699254v1
Volume Number	58
Issue Number	5
Journal	Circulation
Language	English
Access Restriction	Open
Subject Keyword	Aorta Arteriopathic disease Atherosclerosis Blood Platelets Blood supply aspects Coronary Artery Disease Coronary heart disease Coronary sinus structure Patients Platelet Count measurement Platelet aggregation Propranolol Sinus - general anatomical term Tachycardia
Content Type	Text
Resource Type	Article

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