NDLI: Therapeutics , Targets , and Chemical Biology Photodynamic Therapy of Murine Mastocytoma Induces Speci fi c Immune Responses against the Cancer / Testis Antigen P 1 A

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Therapeutics , Targets , and Chemical Biology Photodynamic Therapy of Murine Mastocytoma Induces Speci fi c Immune Responses against the Cancer / Testis Antigen P 1 A

Content Provider	Semantic Scholar
Author	Mróz, Pawel Vatansever, Fatma Muchowicz, Angelika Hamblin, Michael R.
Copyright Year	2013
Abstract	Photodynamic therapy (PDT) involves the intravenous administration of photosensitizers followed by illumination of the tumor with visible light, leading to local production of reactive oxygen species that cause vascular shutdown and tumor cell death. Antitumor immunity is stimulated after PDT because of the acute inflammatory response that involves activation of the innate immune system, leading to stimulation of adaptive immunity. We carried out PDT using benzoporphyrin derivative and 690-nm light after 15 minutes, in DBA/2mice bearing either themastocytoma, P815, which expresses the naturally occurring cancer/testis antigen P1A, or the corresponding tumor P1.204 that lacks P1A expression. Tumor cures, significantly higher survival, and rejection of tumor rechallenge were obtained with P815, which were not seen with P1.204 or seen with P815 growing in nude mice. Both CD4 and CD8 T cells had higher levels of intracellular cytokines when isolated from mice receiving PDT of P815 tumors than P1.204 tumors and CD8 T cells from P815-cured mice recognized the peptide epitope of the P1A antigen (LPYLGWLVF) using pentamer staining. Taken together, these findings show that PDTcan induce a potent antigenand epitope-specific immune response against a naturally occurringmouse tumor antigen. Cancer Res; 73(21); 6462–70. 2013 AACR.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://cancerres.aacrjournals.org/content/canres/73/21/6462.full.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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