Acquired von Willebrand syndrome in children with patent ductus arteriosus.

Content Provider	Semantic Scholar
Author	Rauch, Ralf Budde, Ulrich Koch, A. Girisch, Monika Hofbeck, Michael
Copyright Year	2002
Abstract	Since acquired von Willebrand syndrome (AVWS) was first described in 1968, approximately 270 cases have been reported in the literature. In 12% of these cases AVWS was secondary to cardiovascular disorders. Only two of these reports dealt with children. 3 Gill and colleagues reported on 12 patients with non-cyanotic heart defects (atrial and ventricular septal defects, aortic stenosis) and abnormal von Willebrand factor (VWF) subunits. Four out of five patients with ventricular septal defect who underwent repeat examination following surgical repair showed normalisation of the multimeric pattern. We recently described the first case of AVWS in an infant with persistently patent ductus arteriosus (PDA). To study the frequency of this association and its aetiology, we examined 12 children (eight girls, four boys, median age 3.4 years) who were consecutively admitted for interventional occlusion of a moderate size PDA.
Starting Page	CD000253
Ending Page	CD000253
Page Count	1
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://heart.bmj.com/content/heartjnl/88/1/87.full.pdf
PubMed reference number	12067958v1
Volume Number	88
Issue Number	1
Journal	Heart
Language	English
Access Restriction	Open
Subject Keyword	Aortic Valve Stenosis Cardiovascular Diseases Congenital Heart Defects Heart Atrium Heart Septal Defects Patent ductus arteriosus Patients Structure of ductus arteriosus Sturge-Weber Syndrome Ventricular Septal Defects Von Hippel-Lindau Syndrome von Willebrand factor
Content Type	Text
Resource Type	Article