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Phasic firing time locked to cocaine self-infusion and locomotion: dissociable firing patterns of single nucleus accumbens neurons in the rat.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Peoples, Laura L. Bibi, R. West, Mark O. |
| Copyright Year | 1998 |
| Abstract | The activity of single nucleus accumbens (NAcc) neurons of rats was extracellularly recorded during intravenous cocaine self-administration sessions (0.7 mg/kg per infusion, fixed ratio 1). We reported previously that NAcc neurons showed a change, usually a decrease, in firing rate during the first 1 min after the cocaine-reinforced lever press. This postpress change was followed by a progressive reversal of that change, which began within the first 2 min after the press and was not complete until the last 1 min before the next lever press (termed the change + progressive reversal firing pattern). In the present study we documented a regular pattern of locomotion that occurred in parallel with the change + progressive reversal firing pattern. This observation suggested that discharges time locked to locomotion may determine the change + progressive reversal firing pattern. However, 55% of the neurons failed to show firing time locked to locomotion that could have contributed to the change + progressive reversal firing pattern. Moreover, for all neurons, the change + progressive reversal firing pattern was apparent even if the calculation of firing rate excluded all periods of locomotion. The present data showed that the change + progressive reversal firing pattern is not solely attributable to phasic changes in firing time locked to the execution of locomotion. The change + progressive reversal firing pattern closely mirrors changes in drug level and dopamine overflow observed by previous researchers and may thus be a component of the neurophysiological mechanism by which drug level regulates drug-taking behavior during an ongoing self-administration session. |
| File Format | PDF HTM / HTML |
| DOI | 10.1523/JNEUROSCI.18-18-07588.1998 |
| Alternate Webpage(s) | http://www.eden.rutgers.edu/~mrcoffey/Pubs/Peoples%20FS%20clamp%2098.pdf |
| Alternate Webpage(s) | http://www.rci.rutgers.edu/~markwest/Pubs/Peoples%20FS%20clamp%2098.pdf |
| Alternate Webpage(s) | http://www.jneurosci.org/content/18/18/7588.full.pdf |
| PubMed reference number | 9736676 |
| Alternate Webpage(s) | https://doi.org/10.1523/JNEUROSCI.18-18-07588.1998 |
| Journal | Medline |
| Volume Number | 18 |
| Issue Number | 18 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
