NDLI: Effects of Inorganic Mercury and Methylmercury on the Ionic Currents of Cultured Rat Hippocampal Neurons

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Effects of Inorganic Mercury and Methylmercury on the Ionic Currents of Cultured Rat Hippocampal Neurons

Content Provider	Semantic Scholar
Author	Szücs, Attila Angiello, Christopher Salánki, János Carpenter, David O.
Copyright Year	2004
Abstract	Abstract1. The effects of inorganic Hg2+ and methylmercuric chloride on the ionic currents of cultured hippocampal neurons were studied and compared. We examined the effects of acute exposure to the two forms of mercury on the properties of voltage-activated Ca2+ and Na+ currents and N-methyl-D-aspartate (NMDA)-induced currents.2. High-voltage activated Ca2+ currents (L type) were inhibited by both compounds at low micromolar concentrations in an irreversible manner. Mercuric chloride was five times as potent as methylmercury in blocking L-channels.3. Both compounds caused a transient increase in the low-voltage activated (T-type) currents at low concentrations (1 μM) but blocked at higher concentrations and with longer periods of time.4. Inorganic mercury blockade was partially use dependent, but that by methylmercury was not. There was no effect of exposure of either form of mercury on the I–V characteristics of Ca2+ currents.5. Na+- and NMDA-induced currents were essentially unaffected by either mercury compound, showing only a delayed nonspecific effect at a time of overall damage of the membrane.6. We conclude that both mercury compounds show a relatively selective blockade of Ca2+ currents, but inorganic mercury is more potent than methylmercury.
Starting Page	273
Ending Page	288
Page Count	16
File Format	PDF HTM / HTML
DOI	10.1023/A:1026338217097
Alternate Webpage(s)	https://page-one.springer.com/pdf/preview/10.1023/A:1026338217097
PubMed reference number	9187485
Alternate Webpage(s)	https://doi.org/10.1023/A%3A1026338217097
Journal	Medline
Volume Number	17
Journal	Cellular and Molecular Neurobiology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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