NDLI: Partial escape of HIV-1 from cytotoxic T lymphocytes during chronic infection.

Content Provider	Semantic Scholar
Author	Lewis, Martha Dagarag, Mirabelle D. Khan, Basim Faiqe Noor Ali, Ayub Yang, Otto O.
Copyright Year	2012
Abstract	Viral mutational escape from CD8(+) cytotoxic T lymphocytes (CTLs) is typically considered to be a dichotomous process and uncommon during chronic HIV-1 infection. Ex vivo passaging of HIV-1 from persons with chronic infection, however, revealed the evolution of many fixed substitutions within and around CTL-targeted regions, with an associated increase in replicative capacity. This indicates an evolution of mutations during chronic HIV-1 infection that trade replicative fitness for incomplete evasion of CTLs, or "partial escape."
File Format	PDF HTM / HTML
DOI	10.1128/JVI.06724-11
Alternate Webpage(s)	http://jvi.asm.org/content/86/13/7459.full.pdf
PubMed reference number	22553321
Alternate Webpage(s)	https://doi.org/10.1128/JVI.06724-11
Journal	Medline
Volume Number	86
Issue Number	13
Journal	Journal of virology
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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