NDLI: Self-organizing actin waves as planar phagocytic cup structures.

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Self-organizing actin waves as planar phagocytic cup structures.

Content Provider	Semantic Scholar
Author	Gerisch, Günther Ecke, Mary Schroth-Diez, Britta Gerwig, Silke Engel, Ulrike Maddera, Lucinda Clarke, Margaret
Copyright Year	2009
Abstract	Actin waves that travel on the planar membrane of a substrate-attached cell underscore the capability of the actin system to assemble into dynamic structures by the recruitment of proteins from the cytoplasm. The waves have no fixed shape, can reverse their direction of propagation and can fuse or divide. Actin waves separate two phases of the plasma membrane that are distinguished by their lipid composition. The area circumscribed by a wave resembles in its phosphoinositide content the interior of a phagocytic cup, leading us to explore the possibility that actin waves are in-plane phagocytic structures generated without the localized stimulus of an attached particle. Consistent with this view, wave-forming cells were found to exhibit a high propensity for taking up particles. Cells fed rod-shaped particles produced elongated phagocytic cups that displayed a zonal pattern that reflected in detail the actin and lipid pattern of free-running actin waves. Neutrophils and macrophages are known to spread on surfaces decorated with immune complexes, a process that has been interpreted as "frustrated" phagocytosis. We suggest that actin waves enable a phagocyte to scan a surface for particles that might be engulfed.
Starting Page	2872
Ending Page	2879
Page Count	8
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://pubman.mpdl.mpg.de/pubman/item/escidoc:1579451/component/escidoc:1579450/GerischCAM3-4.pdf
PubMed reference number	19855162v1
Volume Number	3
Issue Number	4
Journal	Cell adhesion & migration
Language	English
Access Restriction	Open
Subject Keyword	Circumscribe (action) Cup Device Component Frustration Fuse Device Component Immune complex Phagocytes Phagocytosis Phosphatidylinositols Plasma membrane Tissue membrane phagocytic cup
Content Type	Text
Resource Type	Article

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