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New vistas on amygdala networks in conditioned fear.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Paré, Denis Quirk, Gregory J. LeDoux, Joseph E. |
| Copyright Year | 2004 |
| Abstract | It is currently believed that the acquisition of classically conditioned fear involves potentiation of conditioned thalamic inputs in the lateral amygdala (LA). In turn, LA cells would excite more neurons in the central nucleus (CE) that, via their projections to the brain stem and hypothalamus, evoke fear responses. However, LA neurons do not directly contact brain stem-projecting CE neurons. This is problematic because CE projections to the periaqueductal gray and pontine reticular formation are believed to generate conditioned freezing and fear-potentiated startle, respectively. Moreover, like LA, CE may receive direct thalamic inputs communicating information about the conditioned and unconditioned stimuli. Finally, recent evidence suggests that the CE itself may be a critical site of plasticity. This review attempts to reconcile the current model with these observations. We suggest that potentiated LA outputs disinhibit CE projection neurons via GABAergic intercalated neurons, thereby permitting associative plasticity in CE. Thus plasticity in both LA and CE would be necessary for acquisition of conditioned fear. This revised model also accounts for inhibition of conditioned fear after extinction. |
| Starting Page | 1 |
| Ending Page | 9 |
| Page Count | 9 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://jn.physiology.org/content/jn/92/1/1.full.pdf |
| Alternate Webpage(s) | http://parelab.rutgers.edu/articles/Pare_etal_JNeurophys.pdf |
| PubMed reference number | 15212433v1 |
| Volume Number | 92 |
| Issue Number | 1 |
| Journal | Journal of neurophysiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Amygdaloid structure Brain Stem Cell Nucleus Central gray substance of midbrain Cerebellar Nuclei Excitation Extinction, Psychological Fear (Mental Process) Freezing Hypothalamic Area, Lateral Hypothalamic structure Interneurons Pontine structure Projection Defense Mechanism Reticular Formation Thalamic structure chemosensitization/potentiation |
| Content Type | Text |
| Resource Type | Article |
