NDLI: Differential Aspergillus lentulus echinocandin susceptibilities are Fksp independent.

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Differential Aspergillus lentulus echinocandin susceptibilities are Fksp independent.

Content Provider	Semantic Scholar
Author	Staab, Janet F. Kahn, Jennifer Nielsen Marr, Kieren A.
Copyright Year	2010
Abstract	The recently described species Aspergillus lentulus exhibits differential and reduced susceptibilities to echinocandins and other antifungal drugs in vitro. A. lentulus isolates overall are less susceptible to caspofungin, although they maintain susceptibility to anidulafungin and micafungin. Mutations or polymorphisms in fks, the gene encoding the catalytic subunit of β-1,3-glucan synthase, are known to confer decreased susceptibility to echinocandins in Candida spp. and Aspergillus fumigatus. The analysis of the A. lentulus fks sequence did not reveal a polymorphism at any of the known hot-spot regions of the gene. Caspofungin and micafungin kinetic inhibition profiles of the A. lentulus glucan synthase were comparable to those from susceptible A. fumigatus enzymes. Although the basal cell wall chitin levels in A. lentulus averaged 60% of those in A. fumigatus, echinocandin treatment promoted the increase of cell wall chitin in both organisms, indicating that A. lentulus displays a compensatory chitin response similar to that of A. fumigatus. The data suggest that differential echinocandin susceptibilities in A. lentulus are independent of the echinocandin target, Fksp, and they emphasize the potential that the drugs' capacity to inhibit the target enzyme is unequal at the cellular level.
Starting Page	33
Ending Page	44
Page Count	12
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://aac.asm.org/content/54/12/4992.full.pdf
PubMed reference number	20855747v1
Alternate Webpage(s)	https://doi.org/10.1128/AAC.00774-10
DOI	10.1128/aac.00774-10
Journal	Antimicrobial agents and chemotherapy
Volume Number	54
Issue Number	12
Language	English
Access Restriction	Open
Subject Keyword	Antifungal Agents Aspergillus fumigatus Basal Cell Caspofungin Catalytic Domain Cell Wall Chitin Disease susceptibility Echinocandins Exhibits as Topic Genetic Polymorphism Kinetics anidulafungin micafungin
Content Type	Text
Resource Type	Article

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