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Bilateral Endoscopic Lung Volume Reduction in Patients with Severe Emphysema.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Lepper, Philipp Moritz Leppert, Daniela Langer, Frank Christoph Lensch, Christian Flaig, Monika Bals, Robert Wilkens, Heinrike Minko, Peter Faehndrich, Sebastian |
| Copyright Year | 2016 |
| Abstract | Reducing hyperinflated areas in chronic obstructive pulmonary disease, either surgically or endoscopically, leads to improvement of functional parameters. It is unclear if bilateral treatment with endobronchial valves (EBV) aiming at total lobar occlusion is beneficial. The aim of this study was to assess the results after staged bilateral endoscopic treatment with EBV. This is a retrospective analysis of patients with severe airflow obstruction, who were treated bilaterally with EBV in two stages, aiming at subsequent atelectasis. Pre- and postintervention lung function parameters, the 6-minute walk test (6-MWT), complications, and follow-up were recorded. Sixteen patients were treated bilaterally in two stages. There was an overall improvement in lung function from baseline to second-treatment follow-up with an increase in FEV1 (23.57-29.21% of predicted) and a decrease in residual volume (299.21-240.10% of predicted) and total lung capacity (140.78-128.71% of predicted). The 6-MWT improved up to 54 m. After each procedure, 9 of 16 patients (56.25%) developed an atelectasis of the target lobe. Overall, pneumothorax occurred in 8 of 32 procedures (25%). No patient died. Patients benefitted from the first EBV treatment. The second treatment did not lead to marked improvements compared to the first treatment. Bilateral lung volume reduction with valves is possible; however, the current results seem not to justify bilateral valve treatment as a routine approach. |
| Starting Page | 356 |
| Ending Page | 358 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://www.karger.com/Article/Pdf/450758 |
| PubMed reference number | 27701180v1 |
| Volume Number | 92 |
| Issue Number | 5 |
| Journal | Respiration; international review of thoracic diseases |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | 6-Minute Walk Test Atelectasis Cessation of life Cholestasis Chronic Obstructive Airway Disease Lung Diseases, Obstructive Lung diseases Mitral Valve Prolapse Syndrome Obstruction Operative Surgical Procedures Patients Pneumothorax Pulmonary Emphysema Respiratory physiology |
| Content Type | Text |
| Resource Type | Article |
