NDLI: Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element.

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Induction of interleukin 6 and interleukin 8 expression by Broncho-Vaxom (OM-85 BV) via C-Fos/serum responsive element.

Content Provider	Semantic Scholar
Author	Keul, Radovan Roth, Michael Papakonstantinou, Eleni D. Nauck, Markus S. Perruchoud, André Paul
Copyright Year	1996
Abstract	BACKGROUND Broncho-Vaxom (OM-85 BV) increases the resistance of the respiratory tract to bacterial infections by modulating host immune responses. The compound increases serum IgG levels but decreases IgE levels in patients suffering from chronic bronchitis or chronic obstructive pulmonary disease. It increases concentrations of gamma-interferon (IFN-gamma), IgA, and interleukin (IL)-2 in bronchoalveolar lavage fluid of patients with bronchitis. Treatment with OM-85 BV increases the number of T helper and natural killer cells. In this study the effects of OM-85 BV on transcription of cytokines is investigated in human lung fibroblasts. METHODS Transcription and synthesis of IL-6 and IL-8 were assessed in cultured primary human lung fibroblasts using standard methods of Northern blot analysis for the level of mRNAs and enzyme linked immunosorbent assay for proteins. RESULTS Broncho-Vaxom (OM-85 BV) at different concentrations induced transcription of IL-6 and IL-8. The effect of the drug on transcription of IL-6 and IL-8 genes correlated with secretion of the proteins into cell supernatants. OM-85 BV-dependent expression of the interleukin genes involved C-Fos/serum responsive element (C-Fos/SRE). CONCLUSIONS The data suggest that the various immunopharmacological activities of OM-85 BV that have been described in clinical studies may be explained by its ability to induce expression of IL-6 and IL-8.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://thorax.bmj.com/content/thoraxjnl/51/2/150.full.pdf
PubMed reference number	8711646v1
Volume Number	51
Issue Number	2
Journal	Thorax
Language	English
Access Restriction	Open
Subject Keyword	Bacterial Infections Bacterial Vaginosis Bronchitis Bronchitis, Chronic Broncho-Vaxom Bronchoalveolar Lavage Fluid Chronic Obstructive Airway Disease Enzyme-Linked Immunosorbent Assay Immunoglobulin A Infection Interferon Type II Interleukin Receptor Common gamma Subunit Interleukins Irrigation Lung Diseases, Obstructive Lung diseases Patients Recombinant Interferon-gamma Respiratory tract structure Structure of parenchyma of lung varicella-zoster immune globulin
Content Type	Text
Resource Type	Article

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