NDLI: Design, synthesis and biological evaluation of novel podophyllotoxin derivatives bearing 4β-disulfide/trisulfide bond as cytotoxic agents

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Design, synthesis and biological evaluation of novel podophyllotoxin derivatives bearing 4β-disulfide/trisulfide bond as cytotoxic agents

Content Provider	Semantic Scholar
Author	Zhu, Shi-Jun Ying, Huazhou Yang, Bo Dong, Xiaowu Hu, Yongzhou
Copyright Year	2015
Abstract	A novel series of C-4β-disulfide/trisulfide-containing podophyllotoxin derivatives were designed, synthesized, and biologically evaluated for their cytotoxic activities against human cancer cell lines, including KB (Mouth Epidermal Carcinoma Cells) and KB/VCR (Vincristine-resistant Mouth Epidermal Carcinoma Cells). Most of these compounds exhibited promising moderate to good cytotoxic activities. In particular, some of them displayed even superior activities to that of etoposide, especially for KB/VCR cell lines, indicating that introduction of the disulfide/trisulfide moiety would be beneficial for overcoming the multi-drug resistant limitation of etoposide. Moreover, the metabolic evaluation of the most promising compound was further performed to reveal that disulfide bond can be stable in human plasma over 8 hours, indicating good potential of these compounds for in vivo anti-cancer activities.
Starting Page	103172
Ending Page	103183
Page Count	12
File Format	PDF HTM / HTML
DOI	10.1039/C5RA12837D
Alternate Webpage(s)	http://www.rsc.org/suppdata/c5/ra/c5ra12837d/c5ra12837d1.pdf
Alternate Webpage(s)	http://pubs.rsc.org/en/content/getauthorversionpdf/C5RA12837D
Alternate Webpage(s)	https://doi.org/10.1039/C5RA12837D
Volume Number	5
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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