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RGD-Based Molecular Probes for Integrin α v β 3 Imaging
| Content Provider | Semantic Scholar |
|---|---|
| Author | Wang, Fan Liu, Zhaofei |
| Copyright Year | 2013 |
| Abstract | The cell adhesion molecule integrin α v β3 is an important player in the process of tumor angiogenesis and metastasis. It is expressed on activated endothelial cells as well as some tumor cells. Non-invasive imaging of integrin α v β3 expression would provide a unique means of characterizing the biological aggressiveness of a malignant tumor in an individual patient. In this chapter, we will summarize the current development and applications of arginine-glycine-aspartic acid (RGD)- based molecular probes for molecular imaging of integrin α v β3 imaging using either a single molecular imaging modality (magnetic resonance imaging, ultrasound, optical, single photon emission computed tomography, and positron emission tomography) or a combination of the different modalities. The strategies that are currently used to optimize the RGD probes will be briefly introduced. |
| Starting Page | 513 |
| Ending Page | 538 |
| Page Count | 26 |
| File Format | PDF HTM / HTML |
| DOI | 10.1007/978-3-642-34303-2_15 |
| Alternate Webpage(s) | https://page-one.springer.com/pdf/preview/10.1007/978-3-642-34303-2_15 |
| Alternate Webpage(s) | https://doi.org/10.1007/978-3-642-34303-2_15 |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
