Loading...
Please wait, while we are loading the content...
Similar Documents
Peripheral nervous system effects in the PS19 tau transgenic mouse model of tauopathy
| Content Provider | Semantic Scholar |
|---|---|
| Author | Merchán-Rubira, Jesús Sebastián-Serrano, Álvaro Díaz-Hernández, Miguel Ávila, Jesús Hernández, Félix |
| Copyright Year | 2019 |
| Abstract | It is well known that transgenic mice overexpressing human tau protein with P301S mutation driven by the mouse prion protein promoter show clasping and limb retraction, hunched back and paralysis, followed by inability to feed that results in death around 12 months of age. To understand these motor deficits, we have carried out rotarod tests on PS19 line and demonstrated how they worsened during aging. Then, we have analyzed if these phenotypic characteristics correlate with sciatic nerve degeneration. We first demonstrated by western blot and immunohistochemistry that the sciatic nerve expresses the transgenic tau protein; then, electron microscopy studies showed alterations in myelin, mainly a detachment of myelin lamellae at Schmidt-Lanterman clefts. Similar motor deficits and myelin alterations have been previously reported in tau knockout and overexpressing transgenic mice; taking into account that PS19 model is widely used to study tauopathies, we suggest that analyzing the expression of transgenic tau protein and myelin abnormalities in the sciatic nerve should be considered when studying some features as motor performance or survival. |
| Starting Page | 204 |
| Ending Page | 208 |
| Page Count | 5 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/j.neulet.2019.01.031 |
| PubMed reference number | 30677432 |
| Journal | Medline |
| Volume Number | 698 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0304394019300424 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0304394019300424?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/j.neulet.2019.01.031 |
| Journal | Neuroscience Letters |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
