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Morphometric analysis of atrioventricular septal defect with common valve orifice.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Suzuki, Kaori Ho, Siew Yen Tatsuno, Katsuhiko Mimori, Shigekazu |
| Copyright Year | 1998 |
| Abstract | OBJECTIVES We sought to analyze morphometric features of atrioventricular septal defect (AVSD) in autopsy specimens and to consider the developmental implications of obstruction in either ventricular outflow tract. BACKGROUND Left ventricular outlet obstruction (LVO) is more prevalent in patients with Rastelli type A morphology. When tetralogy of Fallot (ToF) complicates this malformation, there is usually a free-floating superior bridging leaflet. The reasons for these associations are uncertain. METHODS In 133 hearts with AVSD and common atrioventricular (AV) valve orifice, we measured the degrees of horizontal and anterior deviation of the great arteries from the AV valve, the diameters of the ventricular outlets and the great arteries and the degree of deficiency of the ventricular septum. RESULTS In Rastelli type A morphology, the great arteries were deviated more leftward than in type C morphology (p < 0.01). Type A hearts also had a relatively small aorta, with a long and narrow subaortic tract. The presence of obstruction in either ventricular outlet was associated with a more oblique arrangement of the great arteries, with the pulmonary trunk being more leftward than in hearts without LVO (p < 0.01). In combination with ToF, the aorta was dextroposed and the pulmonary trunk was located more posteriorly (p < 0.01). No heart with type A morphology showed ToF (p < 0.01). CONCLUSIONS The geometric arrangement of the great arteries correlated significantly with obstruction in either ventricular outflow tract and with the Rastelli subtypes. Malrotation of the developing outlet septum may be an embryologic factor producing obstruction, with horizontal deviation of the outlets also influencing the morphology of the superior bridging leaflet. |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.onlinejacc.org/content/accj/31/1/217.full.pdf |
| PubMed reference number | 9426043v1 |
| Volume Number | 31 |
| Issue Number | 1 |
| Journal | Journal of the American College of Cardiology |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anatomical orifice Aorta Arterial system Atrioventricular Septal Defect Cell septum Congenital Abnormality Congenital malrotation of intestine Embryo Heart Septal Defects Heteroralfsia saxicola Hymenasplenium murakami-hatanakae Idiopathic Pulmonary Fibrosis Leaflet Device Component Manuscripts Mental association Obstruction Outflow part of ventricle Patients Premature ventricular contractions Preparation Pulmonary artery structure Septum - general anatomical term Specimen Stenosis Subtype (attribute) Tetralogy of Fallot Thoracic Outlet Syndrome Ventricular septum |
| Content Type | Text |
| Resource Type | Article |
