NDLI: Chromatin , Gene , and RNA Regulation Discovery-Based Protein Expression Pro fi ling Identi fi es Distinct Subgroups and Pathways in Leiomyosarcomas

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Chromatin , Gene , and RNA Regulation Discovery-Based Protein Expression Pro fi ling Identi fi es Distinct Subgroups and Pathways in Leiomyosarcomas

Content Provider	Semantic Scholar
Author	Kirik, Ufuk Hansson, Karin M. Krogh, Morten Nilbert, Mef James, Peter Carneiro, Ana
Copyright Year	2014
Abstract	Soft tissue sarcomas (STS) are malignant tumors of mesenchymal origin. A substantial portion of these tumors exhibits complex karyotypes and lack characterized chromosomal aberrations. Owing to such properties, both histopathologic and molecular classification of these tumors has been a significant challenge. This study examines the protein expression of a large number of human STS, including subtype heterogeneity, using two-dimensional gel proteomics. In addition, detailed proteome profiles of a subset of pleomorphic STS specimens using an in-depth mass-spectrometry approach identified subgroups within the leiomyosarcomas with distinct protein expression patterns. Pathways analysis indicates that key biologic nodes like apoptosis, cytoskeleton remodeling, and telomere regulation are differentially regulated among these subgroups. Finally, investigating the similarities between protein expression of leiomyosarcomas and undifferentiated pleomorphic sarcomas (UPS) revealed similar protein expression profiles for these tumors, in comparison with pleomorphic leiomyosarcomas. Implications: These results suggest that UPS tumors share a similar lineage as leiomyosarcomas and are likely to originate from different stages of differentiation from mesenchymal stem cells to smooth muscle cells.Mol Cancer Res; 12(12); 1729–39. 2014 AACR.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://mcr.aacrjournals.org/content/molcanres/12/12/1729.full.pdf
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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