Depolarization-induced release of ATP from cholinergic synaptosomes is not blocked by botulinum toxin type A

Content Provider	Semantic Scholar
Author	Marsal, Jordi Solsona, Carles Rabasseda, X. Blasi, Joan Casanova, Aurora
Copyright Year	1987
Abstract	We report here the effects of Botulinum Toxin type A on the release of ATP and Acetylcholine from Torpedo electric organ synaptosomes. Our results show that Botulinum Toxin type A inhibits specifically the K(+)-induced release of Acetylcholine from synaptosomes without affecting the release of ATP. Membrane potential and calcium uptake into cholinergic nerve terminals are not modified after Botulinum Toxin poisoning. It is suggested that either most of the ATP released during the depolarization of the cholinergic synaptosomes does not originate from cholinergic synaptic vesicles or that there are two populations of synaptic vesicles, Acetylcholine-enriched synaptic vesicles and ATP-enriched synaptic vesicles. However, the possibility that the ACh and ATP released could come from different intrasynaptosomal compartments cannot be excluded.
Starting Page	295
Ending Page	302
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/0197-0186(87)90103-3
PubMed reference number	20501099
Journal	Medline
Volume Number	10
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/0197018687901033
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/0197018687901033?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/0197-0186%2887%2990103-3
Journal	Neurochemistry International
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article