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Spectrophotometric Determination of Tetracycline by Coupling with Diazotised 4-Aminoantipyrine in Presence of Cetylpyridinium Chloride
| Content Provider | Semantic Scholar |
|---|---|
| Author | Al-Ashow, Rasha J. Othman, Nabeel Sabeh |
| Copyright Year | 2012 |
| Abstract | ABSTRACT A spectrophotometric method for the determination of microgram amounts of tetracycline -HCl(TCH) has been proposed. The method is based on coupling of tetracycline-HCl with diazotized 4-aminoantipyrine in presence of cetylpyridinium chloride in alkaline medium. The molar absorptivity of the formed dye reached to 1.92×10 l.mol. cm at 537 nm and Beers law is obeyed within the range of 10-300 μg of tetracycline-HCl /10 ml (i.e.1.0 – 30 ppm). The colour reaction was highly stable, a relative error ranged from 2.5 to + 0.21 % and a relative standard deviation of ± 0.37 to ± 0.73 %, depending on concentration level of tetracycline-HCl. The proposed method has been applied successfully to the determination of tetracycline-HCl in pharmaceutical preparations. |
| Starting Page | 72 |
| Ending Page | 84 |
| Page Count | 13 |
| File Format | PDF HTM / HTML |
| Volume Number | 23 |
| Alternate Webpage(s) | https://www.iasj.net/iasj?aId=44397&func=fulltext |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
