NDLI: Short-term effects of sleeve gastrectomy on type 2 diabetes mellitus in severely obese subjects.

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Short-term effects of sleeve gastrectomy on type 2 diabetes mellitus in severely obese subjects.

Content Provider	Semantic Scholar
Author	Vidal, Josep Ibarzábal, Ainitze Nicolau, Joana Vidov, M. Delgado, Salva Balust, Jaume Morínigo, Rosa A. Lacy, Antonio
Copyright Year	2007
Abstract	BACKGROUND Data on the effectiveness of sleeve gastrectomy (SG) in improving or resolving type 2 diabetes mellitus (T2DM) are scarce. METHODS A 4-month prospective study was conducted on the changes in glucose homeostasis in 35 severely obese T2DM subjects undergoing laparoscopic SG (LSG) and 50 subjects undergoing laparoscopic Roux-en-Y gastric bypass (LRYGBP), matched for DM duration, type of DM treatment, and glycemic control. RESULTS At 4-months after surgery, LSG and LRYGBP operated subjects lost a similar amount of weight (respectively, 20.6 +/- 0.7% and 21.0 +/- 0.6%). T2DM had resolved respectively in 51.4% and 62.0% of the LSG and LRYGBP operated subjects (P = 0.332). A shorter preoperative DM duration (P < 0.05), a preoperative DM treatment not including pharmacological agents, and a better pre-surgical fasting plasma glucose (P < 0.01) or HbAlc (P < 0.01), were significantly associated with a better type 2 DM outcome in both surgical groups. CONCLUSIONS Our data show that LSG and LRYGBP result in a similar rate of type 2 DM resolution at 4-months after surgery. Moreover, our data suggest that mechanisms beyond weight loss may be implicated in DM resolution following LSG and LRYGBP.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.bmihk.info/download/LSG%20DM.pdf
PubMed reference number	17953241v1
Volume Number	17
Issue Number	8
Journal	Obesity surgery
Language	English
Access Restriction	Open
Subject Keyword	Dexamethasone Diabetes Mellitus Diabetes Mellitus, Non-Insulin-Dependent Gastrectomy Gastric Bypass Glucose Metabolism Disorders How Often Weight Loss Obesity Pharmacology Postgastrectomy Syndromes Stomach Neoplasms
Content Type	Text
Resource Type	Article

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