NDLI: Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1.

Please wait, while we are loading the content...

Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1.

Content Provider	Semantic Scholar
Author	Chapman, Timothy Ross Barrientos, Ruth M. Ahrendsen, Jared T. Maier, Steven F. Patterson, Susan L.
Copyright Year	2010
Abstract	Variability in cognitive functioning increases markedly with age, as does cognitive vulnerability to physiological and psychological challenges. Exploring the basis of this vulnerability may provide important insights into the mechanisms underlying aging-associated cognitive decline. As we have previously reported, the cognitive abilities of aging (24-month-old) F344 x BN rats are generally good, but are more vulnerable to the consequences of a peripheral immune challenge (an intraperitoneal injection of live Escherichia coli) than those of their younger (3-month-old) counterparts. Four days after the injection, the aging, but not the young rats show profound memory deficits, specific to the consolidation of hippocampus-dependent memory processes. Here, we have extended these observations, using hippocampal slices to examine for the first time the combined effects of aging and a recent infection on several forms of synaptic plasticity. We have found that the specific deficit in long-lasting memory observed in the aged animals after infection is mirrored by a specific deficit in a form of long-lasting synaptic plasticity. The late-phase long-term potentiation induced in area CA1 using theta-burst stimulation is particularly compromised by the combined effects of aging and infection-a deficit that can be ameliorated by intra-cisterna magna administration of the naturally occurring antiinflammatory cytokine IL-1Ra (interleukin-1 receptor antagonist). These data support the idea that the combination of aging and a negative life event such as an infection might produce selective, early-stage failures of synaptic plasticity in the hippocampus, with corresponding selective deficits in memory.
Starting Page	445
Ending Page	449
Page Count	5
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://www.jneurosci.org/content/jneuro/30/22/7598.full.pdf
Alternate Webpage(s)	http://psych.colorado.edu/~patters/Synaptic-Correlates.pdf
PubMed reference number	20519534v1
Alternate Webpage(s)	https://doi.org/10.1523/JNEUROSCI.5172-09.2010
DOI	10.1523/jneurosci.5172-09.2010
Journal	The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume Number	30
Issue Number	22
Language	English
Access Restriction	Open
Subject Keyword	Aging Anti-Inflammatory Agents CA1 field Cognition Disorders Injections, Intraperitoneal Long-Term Potentiation Lung consolidation Memory Disorders Neuronal Plasticity Rats, Inbred F344 Structure of cisterna magna chemosensitization/potentiation cytokine
Content Type	Text
Resource Type	Article

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Synaptic Correlates Of Increased Cognitive Vulnerability With Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst L-LTP in Hippocampal Area CA1

Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats.

Homosynaptic and heterosynaptic inhibition of synaptic tagging and capture of long-term potentiation by previous synaptic activity.

Dynamic synapses as archives of synaptic history: state-dependent redistribution of synaptic efficacy in the rat hippocampal CA1.

Priming-induced shift in synaptic plasticity in the rat hippocampus.

Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice.

Short-term plasticity and long-term potentiation mimicked in single inorganic synapses.

Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area ca1 (2007).

Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.

Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1.

Similar Documents

Synaptic Correlates Of Increased Cognitive Vulnerability With Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst L-LTP in Hippocampal Area CA1

Theta-frequency synaptic potentiation in CA1 in vitro distinguishes cognitively impaired from unimpaired aged Fischer 344 rats.

Homosynaptic and heterosynaptic inhibition of synaptic tagging and capture of long-term potentiation by previous synaptic activity.

Dynamic synapses as archives of synaptic history: state-dependent redistribution of synaptic efficacy in the rat hippocampal CA1.

Priming-induced shift in synaptic plasticity in the rat hippocampus.

Associative learning and CA3-CA1 synaptic plasticity are impaired in D1R null, Drd1a-/- mice and in hippocampal siRNA silenced Drd1a mice.

Short-term plasticity and long-term potentiation mimicked in single inorganic synapses.

Aging effects on the limits and stability of long-term synaptic potentiation and depression in rat hippocampal area ca1 (2007).

Hippocampal long-term depression and long-term potentiation encode different aspects of novelty acquisition.

Synaptic correlates of increased cognitive vulnerability with aging: peripheral immune challenge and aging interact to disrupt theta-burst late-phase long-term potentiation in hippocampal area CA1.