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P.2.d.028: Distinct symptom profiles in unipolar and bipolar depression based on the neurocircuitry theory
| Content Provider | Semantic Scholar |
|---|---|
| Author | Szegő, Andrea Sárosi, Andrea Dome, Péter Demeter, Zsolt Gonda, Xenia |
| Copyright Year | 2016 |
| Abstract | Depression is a heterogeneous disorder manifesting with distinct clinical pictures re㤵〰ecting differential involvement of neurotransmitter systems and neurocircuitry pathways in the background of symptoms, constituting a challenge for proper diagnosis and effective pharmacological treatment. Separating unipolar and bipolar acute depressive episodes in the lack of previous manic or hypomanic episodes is a challenging task. Treatment of various subtypes of unipolar and bipolar depressive episodes both acutely and in the long term requires different pharmacotherapeutic approaches in part due to different neurochemical mechanisms. With a signi㰊浔cant rate of depressive episodes nonresponsive to treatment, and these being predominantly bipolar, both understanding the neuroanatomical and neurochemical underpinnings of depressive episode subtypes and more accurate differential diagnosis would be a crucial step towards more effective treatment. The majority of instruments assessing depression provide a single composite score but no means to establish a cross-sectional detailed symptom pro㰊浔le to indicate the presence and relative weight of individual depressive symptoms also re㤵〰ecting differences in neurobiology. Depression Pro㰊浔le [1], including 102 items (90 referring to symptoms of depression and 12 to previous (hypo)manic symptoms) and yielding 14 symptom clusters was developed based on the neurocircuitry theory [2] describing the neurobiological background of major depressive symptoms to selectively assess symptom clusters associated with different (1) (1) (1) (1) (1) (1) |
| Starting Page | s435 |
| Ending Page | s436 |
| Page Count | 2 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/S0924-977X(16)31415-8 |
| Volume Number | 26 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/S0924977X16314158 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/S0924977X16314158?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | http://real.mtak.hu/40270/1/szego.pdf |
| Alternate Webpage(s) | https://doi.org/10.1016/S0924-977X%2816%2931415-8 |
| Journal | European Neuropsychopharmacology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Synopsis |
