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A cholinergic innervation of the bovine pineal gland visualized by immunohistochemical detection of choline acetyltransferase-immunoreactive nerve fibers
| Content Provider | Semantic Scholar |
|---|---|
| Author | Phansuwan-Pujito, Pansiri Mikkelsen, Jens Damsgaard Govitrapong, Piyarat Møller, Morten |
| Copyright Year | 1991 |
| Abstract | An immunohistochemical investigation of the bovine pineal gland was performed using both a rabbit polyclonal antibody and a rat monoclonal antibody against choline acetyltransferase (ChAT). A network of ChAT-immunoreactive (IR) nerve fibers was located throughout the pineal gland, both in the perivascular spaces and between the pinealocytes. Most of the intrapineal ChAT-IR nerve fibers were endowed with varicosities. In addition, some ChAT-IR intrapineal neurons were found, often located at the base of the gland near the pineal recess. Within the habenular nucleus and pineal stalk, ChAT-IR perikarya and nerve fibers were also present. Some of these fibers projected towards the pineal gland. A number of ChAT-IR nerves were also located in the posterior commissure and could be followed into the gland. At the caudal tip of the pineal gland, a bundle of ChAT-IR nerve fibers was observed to penetrate into the gland together with blood vessels. The presence of a cholinergic innervation of the bovine pineal gland, together with previous demonstration of the presence of choline acetyltransferase and muscarinic receptor binding sites in the bovine pineal gland, indicates a functional influence of a cholinergic nervous system on the pinealocyte. |
| Starting Page | 49 |
| Ending Page | 58 |
| Page Count | 10 |
| File Format | PDF HTM / HTML |
| DOI | 10.1016/0006-8993(91)91268-6 |
| PubMed reference number | 1860060 |
| Journal | Medline |
| Volume Number | 545 |
| Alternate Webpage(s) | https://api.elsevier.com/content/article/pii/0006899391912686 |
| Alternate Webpage(s) | https://www.sciencedirect.com/science/article/pii/0006899391912686?dgcid=api_sd_search-api-endpoint |
| Alternate Webpage(s) | https://doi.org/10.1016/0006-8993%2891%2991268-6 |
| Journal | Brain Research |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
