NDLI: Investigation of the effects of drugs effective on PI 3 K-AKT signaling pathway in colorectal cancer alone and in combination

Please wait, while we are loading the content...

Investigation of the effects of drugs effective on PI 3 K-AKT signaling pathway in colorectal cancer alone and in combination

Content Provider	Semantic Scholar
Author	Temiz, Tijen Kaya Altun, Ahmet Turgut, Nergiz Balcı, Ezgi
Copyright Year	2014
Abstract	Aim. This study was designed to determine the agent and/or possible agent combinations that may be effective in the treatment of colorectal cancer. For this reason the single and combined antiproliferative effects of NVPBEZ-235, API-1, LY 294002 and PP242 which target PI3K/AKT pathway well known to have an important role in pathophysiological mechanisms of colorectal cancer were investigated. We investigated whether NVPBEZ-235, API-1 and PP242 have antiproliferative effects which have not been studied on this cancer type and also compared the effects with LY294002 known to have antiproliferative effect on colorectal cancer. Method. DLD1 cell line was used as colorectal cells. Real time cell analysis (xCELLigence system) was used to determine the effects of the agents in colorectal cell proliferation. Results. When the agents were applied alone, PI3K/mTOR dual inhibitor NVP-BEZ had the strongest cytotoxic effect and PI3K inhibitor LY294002 had the lowest cytotoxic effect. None of the combinations were not superior compared to alone applications. Conclusion. This study indicates that when PI3K/AKT pathway is targeted, instead of combined treatment, targeted specific treatment with a single agent having higher affinity and effectiveness would be more appropriate. Also among the agents effecting PI3K/AKT pathway especially, NVP-BEZ for targeted therapy can be alternative to conventional treatments.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://dergipark.gov.tr/download/article-file/48103
Language	English
Access Restriction	Open
Subject Keyword	1-Phosphatidylinositol 3-Kinase Cell Proliferation Colorectal Carcinoma Combined Modality Therapy Dual Gene regulatory network LY 294002 N-version programming NVP ABE171 Neoplasms Nevirapine PP242 Processor affinity Proto-Oncogene Proteins c-akt Signal Transduction Pathways
Content Type	Text
Resource Type	Article

Central Library (ISO-9001:2015 Certified)
Indian Institute of Technology Kharagpur
Kharagpur, West Bengal, India | PIN - 721302

See location in the Map
03222 282435
Mail: support@ndl.gov.in

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in