Isolation rearing of mice induces deficits in prepulse inhibition of the startle response

Content Provider	Semantic Scholar
Author	Varty, Geoffrey B. Powell, Susan B. Lehmann-Masten, Virginia D. Buell, Mahálah R. Geyer, Mark A.
Copyright Year	2006
Abstract	Male 129T2 and C57BL/6J mice were housed either in groups of three (socials) or singly (isolates) at weaning. Six and seven weeks later, prepulse inhibition (PPI), startle reactivity, and locomotor activity (LMA) were measured. Isolation-reared mice of both strains exhibited PPI deficits compared to socially reared controls in at least one of the two PPI test sessions. Isolation rearing had no effect on startle reactivity or habituation and only 129T2 isolates exhibited increased LMA. Isolation rearing induced locomotor hyperactivity and PPI deficits in mice and may be an effective developmental manipulation to use in combination with studies of genetically altered mice.
Starting Page	162
Ending Page	167
Page Count	6
File Format	PDF HTM / HTML
DOI	10.1016/j.bbr.2005.11.025
PubMed reference number	16406103
Journal	Medline
Volume Number	169
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0166432805005188
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0166432805005188?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.bbr.2005.11.025
Journal	Behavioural Brain Research
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article