Loading...
Please wait, while we are loading the content...
Similar Documents
The long non-coding RNA HOXB-AS3 regulates ribosomal RNA transcription in NPM1-mutated acute myeloid leukemia
| Content Provider | Semantic Scholar |
|---|---|
| Author | Papaioannou, Dimitrios Petri, Andreas Dovey, Oliver M. Terreri, Sara Wang, Eric Collins, Frances A. Woodward, Lauren A. Walker, Allison E. Nicolet, Deedra Pepe, Felice Kumchala, Prasanthi Bill, Marius Walker, Christopher J. Karunasiri, Malith S. Mrózek, Krzysztof Gardner, Miranda L. Camilotto, Virginia Zitzer, Nina Cooper, Jonathan L. Cai, Xiongwei Rong-Mullins, Xiaoqing Kohlschmidt, Jessica Archer, Kellie J. Freitas, Michael A. Zheng, Yi Lee, Robert J. Aifantis, Iannis Vassiliou, George S. Singh, Guramrit Kauppinen, Sakari Bloomfield, Clara D. Dorrance, Adrienne M. Garzon, Ramiro |
| Copyright Year | 2019 |
| Abstract | Long non-coding RNAs (lncRNAs) are important regulatory molecules that are implicated in cellular physiology and pathology. In this work, we dissect the functional role of the HOXB-AS3 lncRNA in patients with NPM1-mutated (NPM1mut) acute myeloid leukemia (AML). We show that HOXB-AS3 regulates the proliferative capacity of NPM1mut AML blasts in vitro and in vivo. HOXB-AS3 is shown to interact with the ErbB3-binding protein 1 (EBP1) and guide EBP1 to the ribosomal DNA locus. Via this mechanism, HOXB-AS3 regulates ribosomal RNA transcription and de novo protein synthesis. We propose that in the context of NPM1 mutations, HOXB-AS3 overexpression acts as a compensatory mechanism, which allows adequate protein production in leukemic blasts. LncRNAs at the HOX gene locus are increased in expression in NPM1 mutant acute myeloid leukemia. In this study, the authors show that one such lncRNA, HOX3B-AS3, has a role in regulating gene transcription and protein synthesis in leukemia cells. |
| File Format | PDF HTM / HTML |
| DOI | 10.1038/s41467-019-13259-2 |
| PubMed reference number | 31767858 |
| Journal | Medline |
| Volume Number | 10 |
| Alternate Webpage(s) | https://vbn.aau.dk/ws/portalfiles/portal/315887365/s41467_019_13259_2.pdf |
| Alternate Webpage(s) | https://www.repository.cam.ac.uk/bitstream/handle/1810/299643/The%20long%20non-coding%20RNA%20HOXB-AS3%20regulates%20ribosomal%20RNA%20transcription%20in%20NPM1-mutated%20acute%20myeloid%20leukemia.pdf?isAllowed=y&sequence=1 |
| Alternate Webpage(s) | https://doi.org/10.1038/s41467-019-13259-2 |
| Journal | Nature Communications |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |
