NDLI: A reagentless biosensor of nitric oxide based on direct electron transfer process of cytochrome c on multi-walled carbon nanotube.

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A reagentless biosensor of nitric oxide based on direct electron transfer process of cytochrome c on multi-walled carbon nanotube.

Content Provider	Semantic Scholar
Author	Zhao, Guang-Chao Yin, Zheng-Zhi Wei, Xian-Wen
Copyright Year	2005
Abstract	Direct electron transfer between Cytochrome c (Cyt.c) and electrode can be achieved through immobilizing Cyt.c on the surface of multi-walled carbon nanotubes (MWNTs). Under the condition of cyclic potential scans, Cyt.c can be adsorbed on the surface of MWNTs that were modified on a glassy carbon (GC) electrode to form an approximate monolayer. The redox characteristic and bioactivity of Cyt.c could be remained after it was adsorbed on MWNTs' surface. This provides a way to construct a new biosenser based on the activity of Cyt.c. Further investigation displayed that Cyt.c adsorbed on MWNTs showed an enzyme-like activity to catalyze the reduction of nitric oxide (NO). Due to catalyzing by Cyt.c, the reduction of NO in aqueous solution was achieved, which reductive potential appeared at -0.747V (vs. SCE). The peak currents were linearly proportional to concentration of NO in the range from 2 to 48 micromol/l with a limit of detection of 1.3 microM. The biosensor showed a good stability and excellent repeatability.
File Format	PDF HTM / HTML
PubMed reference number	15970472
Journal	Medline
Volume Number	10
Alternate Webpage(s)	https://www.bioscience.org/fbs/getfile.php?FileName=/2005/v10/af/1675/1675.pdf
Journal	Frontiers in bioscience : a journal and virtual library
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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