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Prenatal drug exposure affects neonatal brain functional connectivity.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Salzwedel, Andrew P. Grewen, Karen M. Vachet, Clement Gerig, Guido Lin, Weili Gao, Wei |
| Copyright Year | 2015 |
| Abstract | Prenatal drug exposure, particularly prenatal cocaine exposure (PCE), incurs great public and scientific interest because of its associated neurodevelopmental consequences. However, the neural underpinnings of PCE remain essentially uncharted, and existing studies in school-aged children and adolescents are confounded greatly by postnatal environmental factors. In this study, leveraging a large neonate sample (N = 152) and non-invasive resting-state functional magnetic resonance imaging, we compared human infants with PCE comorbid with other drugs (such as nicotine, alcohol, marijuana, and antidepressant) with infants with similar non-cocaine poly drug exposure and drug-free controls. We aimed to characterize the neural correlates of PCE based on functional connectivity measurements of the amygdala and insula at the earliest stage of development. Our results revealed common drug exposure-related connectivity disruptions within the amygdala-frontal, insula-frontal, and insula-sensorimotor circuits. Moreover, a cocaine-specific effect was detected within a subregion of the amygdala-frontal network. This pathway is thought to play an important role in arousal regulation, which has been shown to be irregular in PCE infants and adolescents. These novel results provide the earliest human-based functional delineations of the neural-developmental consequences of prenatal drug exposure and thus open a new window for the advancement of effective strategies aimed at early risk identification and intervention. |
| Starting Page | 1314 |
| Ending Page | 1320 |
| Page Count | 7 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://www.sci.utah.edu/publications/Sal2015b/salzwedel_jns_2015.pdf |
| Alternate Webpage(s) | http://www.jneurosci.org/content/jneuro/35/14/5860.full.pdf |
| PubMed reference number | 25855194v1 |
| Alternate Webpage(s) | https://doi.org/10.1523/JNEUROSCI.4333-14.2015 |
| DOI | 10.1523/jneurosci.4333-14.2015 |
| Journal | The Journal of neuroscience : the official journal of the Society for Neuroscience |
| Volume Number | 35 |
| Issue Number | 14 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Adolescent (age group) Amygdaloid structure Antidepressive Agents Arousal Comorbid condition:Find:Pt:^Patient:Nom Ethanol Infant Infant, Newborn Insula of Reil Nicotine Poly A Rest fMRI prenatal cocaine exposure |
| Content Type | Text |
| Resource Type | Article |
