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Atrial fibrillation, valvular heart disease, and use of target-specific oral anticoagulants for stroke prevention.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Hohnloser, Stefan Hans Lopes, Renato D. |
| Copyright Year | 2014 |
| Abstract | This editorial refers to ‘Clinical characteristics and outcomes with rivaroxaban vs. warfarin in patients with non-valvular atrial fibrillation but underlying native mitral and aortic valve disease participating in the ROCKET AF trial’[†][1], by G. Breithardt et al. on page 3377. With the introduction of the target-specific oral anticoagulants (TSOAs), primary and secondary stroke prevention in atrial fibrillation (AF) has been revolutionized. Large randomized clinical trials and subsequent meta-analyses have clearly demonstrated that these agents have at least comparable if not superior efficacy and cause no more or even less major bleeding than vitamin K antagonists.1–5 The improved safety profile of these new compounds is particularly reflected by the significantly reduced risk of intracranial bleeds in comparison with warfarin, a property which all TSOAs have in common.6 Because of the historical studies on stroke prevention in patients with AF, all of the pivotal trials of TSOAs were conducted in patients with non-valvular AF, defined as patients with AF without rheumatic valve disease (mainly severe/moderate mitral stenosis) and/or without prosthetic heart valves. All other types of valve disease such as mitral regurgitation, aortic regurgitation, or aortic stenosis, for example, were allowed to be included in these trials. However, the historical term ‘non-valvular AF’ recently used in TSOA studies has created some confusion and led to concerns about the use of the TSOAs in patients with AF and valvular abnormalities. The recently published European and North American recommendations for management of AF have defined valvular AF as AF related … [1]: #fn-2 |
| Starting Page | 82 |
| Ending Page | 84 |
| Page Count | 3 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | https://oup.silverchair-cdn.com/oup/backfile/Content_public/Journal/eurheartj/35/47/10.1093_eurheartj_ehu386/3/ehu386.pdf?Expires=1492945278&Key-Pair-Id=APKAIUCZBIA4LVPAVW3Q&Signature=Qe8uAj29ei2B95icim5SfN2mKPc07gpIbexrxRTd3fTibv83JGU2jeiC6xaK3B-0SB99VTxWklk0~BJsDn1ibYElqzjiCN9EvypOnvg6ApZTQ0QQ7zZ~kimfgdaQEost2HWwbfXhX7T9CHwRvuof2t8spTkacb~B1ZhKn~xSM2oByENhqAIUYz60w-lGkknhTmdDqAxJcQ5MvEoZRD-yAPYL6jpYX0WeJphs3wgnBz38y8Wg~mGixIBcdyOof~Ct3tbu~4~8BvdNHT84J3KiscJV6XBYlygKdv9l2jqoq7K~uwz-t3LVmaEuxLFnVI79J5Vpkor1K5l11cbaJho1uw__ |
| PubMed reference number | 25336222v1 |
| Alternate Webpage(s) | https://doi.org/10.1093/eurheartj/ehu386 |
| DOI | 10.1093/eurheartj/ehu386 |
| Journal | European heart journal |
| Volume Number | 35 |
| Issue Number | 47 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Anticoagulants Aortic Valve Insufficiency Aortic Valve Stenosis Arteriopathic disease Atrial Fibrillation Cerebrovascular accident Confusion Congenital Abnormality Coronary Artery Bypass Surgery Embolism Exclusion Heart Atrium Heart Diseases Heart Valves Heart failure Heart valve disease Hemorrhage Intracranial Aneurysm Meta Analysis (statistical procedure) Mitral Valve Insufficiency Mitral Valve Prolapse Syndrome Mitral Valve Stenosis Mitral valvuloplasty Myocardial Infarction Patients Peripheral Arterial Diseases Regurgitation Renal Insufficiency Scientific Publication Subgroup Valvular disease Ventricular Fibrillation Vitamin K Warfarin apixaban dabigatran rheumatic valvulitis rivaroxaban |
| Content Type | Text |
| Resource Type | Article |
