NDLI: Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca(2+)-Mobilizing Second Messenger.

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Design, Synthesis, and Identification of 4″α-Azidoethyl-cyclic ADP-Carbocyclic-ribose as a Highly Potent Analogue of Cyclic ADP-Ribose, a Ca(2+)-Mobilizing Second Messenger.

Content Provider	Semantic Scholar
Author	Sato, Takatoshi Watanabe, Mizuki Tsuzuki, Takayoshi Takano, Satoshi Murayama, Takashi Sakurai, Takashi Kameda, Tomoshi Fukuda, Hayato Arisawa, Mitsuhiro Shuto, Satoshi
Copyright Year	2016
Abstract	Cyclic adenosine diphosphate-carbocyclic-ribose (cADPcR, 2) is a stable equivalent of cyclic adenosine diphosphate-ribose (cADPR, 1), a Ca(2+)-mobilizing second messenger. On the basis of the structure-activity relationship of cADPR-related compounds and three-dimensional structural modeling of cADPcR, we designed and synthesized cyclic-ADP-4″α-azidoethyl carbocyclic-ribose (N3-cADPcR, 3) to demonstrate that it has a highly potent Ca(2+)-mobilizing activity (EC50 = 24 nM). N3-cADPcR will be a useful precursor for the preparation of biological tools effective to investigate cADPR-mediated signaling pathways.
File Format	PDF HTM / HTML
DOI	10.1021/acs.jmedchem.6b00437
PubMed reference number	27391373
Journal	Medline
Volume Number	59
Issue Number	15
Alternate Webpage(s)	http://wxjs.chinayyhg.com/upload/Files/20161205200455221/7282-7286.pdf
Alternate Webpage(s)	https://doi.org/10.1021/acs.jmedchem.6b00437
Journal	Journal of medicinal chemistry
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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