NDLI: Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein.

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Increased fecal bile acid excretion in transgenic mice with elevated expression of human phospholipid transfer protein.

Content Provider	Semantic Scholar
Author	Crom, Rini De Haperen, Rien Van Tol, Arie Van
Copyright Year	2003
Abstract	OBJECTIVE HDL plays a key role in protection against development of atherosclerosis by promoting reverse cholesterol transport from peripheral tissues to the liver for secretion into bile. Phospholipid transfer protein (PLTP) promotes the transfer of phospholipids between lipoproteins and modulates HDL size and composition, thereby having a crucial role in HDL metabolism. We investigated the effect of increased PLTP activity on removal of cholesterol from the body. METHODS AND RESULTS On a chow diet, transgenic mice overexpressing human PLTP have a 15-fold increased plasma PLTP activity compared with wild-type mice (572.4+/-59.2 versus 38.6+/-3.6 micromol/mL per h). Plasma cholesterol, mainly present in HDL, is strongly decreased (-92%), caused by a rapid clearance from the circulation by the liver and leading to a 1.8-fold increase in hepatic cholesteryl esters. This results in a 2-fold increase in biliary bile acid secretion without changing the bile saturation index. Consequently, the transgenic mice show a 1.4-fold increase in the amount of excreted fecal bile acids compared with wild-type mice, whereas fecal neutral sterol excretion is unchanged. CONCLUSIONS Our data show that elevation of PLTP activity results in rapid disposal of cholesterol from the body via increased conversion into bile acids and subsequent excretion.
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Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/23/5/892.full.pdf
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/23/5/892.full.pdf?download=true
Alternate Webpage(s)	http://atvb.ahajournals.org/content/atvbaha/early/2003/03/20/01.ATV.0000067702.22390.20.full.pdf
Alternate Webpage(s)	http://atvb.ahajournals.org/content/23/5/892.full.pdf
PubMed reference number	12649089v1
Volume Number	23
Issue Number	5
Journal	Arteriosclerosis, thrombosis, and vascular biology
Language	English
Access Restriction	Open
Subject Keyword	Atherosclerosis Bile Acids Bile duct carcinoma Bile fluid Body tissue Cholesterol Esters Disposal Lipoproteins Liver diseases Micromole PLTP gene Phospholipids Promotion (action) Thioctic Acid bile acid secretion chow chow
Content Type	Text
Resource Type	Article

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