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Recombinant vaccinia virus expressing the herpes simplex virus type 1 glycoprotein C protects mice against herpes simplex virus challenge.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Weir, Jerry P. Bennett, Malcolm Allen, Elizabeth M. Elkins, Karen L. MartÃn, Sonsoles Rouse, Barry T. |
| Copyright Year | 1989 |
| Abstract | The gene encoding the herpes simplex virus type 1 (HSV-1) glycoprotein C (gC) was isolated and cloned into a vaccinia virus insertion vector, and the resulting vaccinia-gC vector was used to construct a recombinant vaccinia virus that expressed gC (VVgC5). Infection of cells with VVgC5 resulted in cell surface expression of authentic HSV-1 gC. HSV-1 gC-specific neutralizing antibodies were produced in VVgC5-immunized mice, and lymphocytes exhibited an HSV-1-specific proliferation response in vitro following infection. More importantly, VVgC5-immunized mice were resistant to subsequent lethal HSV-1 challenge. |
| File Format | PDF HTM / HTML |
| DOI | 10.1099/0022-1317-70-10-2587 |
| Alternate Webpage(s) | https://www.microbiologyresearch.org/docserver/fulltext/jgv/70/10/JV0700102587.pdf?accname=guest&checksum=CB1D7501891C3F4A6C3DE1A30FD3D317&expires=1546453803&id=id |
| Alternate Webpage(s) | https://www.microbiologyresearch.org/docserver/fulltext/jgv/70/10/JV0700102587.pdf?accname=guest&checksum=77D3D7B87D41463209D7D8A4013B24EC&expires=1556395347&id=id |
| Alternate Webpage(s) | http://www.microbiologyresearch.org/docserver/fulltext/jgv/70/10/JV0700102587.pdf?accname=guest&checksum=6C9F3B06C64120A732148F92E212AB52&expires=1541353906&id=id |
| PubMed reference number | 2794972 |
| Alternate Webpage(s) | https://doi.org/10.1099/0022-1317-70-10-2587 |
| Journal | Medline |
| Volume Number | 70 |
| Part | 10 |
| Journal | The Journal of general virology |
| Language | English |
| Access Restriction | Open |
| Content Type | Text |
| Resource Type | Article |