Neuropsychological measures that detect early impairment and decline in preclinical Alzheimer disease

Content Provider	Semantic Scholar
Author	Schindler, Suzanne Elizabeth Jasielec, Mateusz S. Weng, Hua Hassenstab, Jason J. Fagan, Anne M.
Copyright Year	2017
Abstract	Identifying which neuropsychological measures detect early cognitive changes associated with Alzheimer disease (AD), brain pathology would be helpful clinically for the diagnosis of early AD and for the design of clinical trials. We evaluated which neuropsychological measures in our cognitive battery are most strongly associated with cerebrospinal fluid (CSF) biomarkers of AD brain pathology. We studied a large cohort (n = 233) of middle-to older-aged community-dwelling individuals (mean age 61 years) who had no clinical symptoms of dementia and underwent baseline CSF collection at baseline. Participants completed a battery of 9 neuropsychological measures at baseline and then every 1 to 3 years. CSF tau/Aβ42 was associated with baseline performance on 5/9 neuropsychological measures, especially measures of episodic memory, and longitudinal performance on 7/9 neuropsychological measures, especially measures of global cognition. The free recall portion of the Free and Cued Selective Reminding Task (FCSRT-free) detected declining cognition in the high CSF tau/Aβ42 group the earliest, followed by another measure of episodic memory and a sequencing task.
Starting Page	25
Ending Page	32
Page Count	8
File Format	PDF HTM / HTML
DOI	10.1016/j.neurobiolaging.2017.04.004
PubMed reference number	28482211
Journal	Medline
Volume Number	56
Alternate Webpage(s)	https://api.elsevier.com/content/article/pii/S0197458017301227
Alternate Webpage(s)	https://www.sciencedirect.com/science/article/pii/S0197458017301227?dgcid=api_sd_search-api-endpoint
Alternate Webpage(s)	https://doi.org/10.1016/j.neurobiolaging.2017.04.004
Journal	Neurobiology of Aging
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article