NDLI: Bacterial mode of replication with eukaryotic-like machinery in a hyperthermophilic archaeon.

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Bacterial mode of replication with eukaryotic-like machinery in a hyperthermophilic archaeon.

Content Provider	Semantic Scholar
Author	Myllykallio, Hannu Lopez, Philippe López-García, Purificación Zivanovic, Yvan Philippe, Herve Forterre, Patrick
Copyright Year	2000
Abstract	Despite a rapid increase in the amount of available archaeal sequence information, little is known about the duplication of genetic material in the third domain of life. We identified a single origin of bidirectional replication in Pyrococcus abyssi by means of in silico analyses of cumulative oligomer skew and the identification of an early replicating chromosomal segment. The replication origin in three Pyrococcus species was found to be highly conserved, and several eukaryotic-like DNA replication genes were clustered around it. As in Bacteria, the chromosomal region containing the replication terminus was a hot spot of genome shuffling. Thus, although bacterial and archaeal replication proteins differ profoundly, they are used to replicate chromosomes in a similar manner in both prokaryotic domains.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://max2.ese.u-psud.fr/publications/pdf14.pdf
PubMed reference number	10864870v1
Volume Number	288
Issue Number	5474
Journal	Science
Language	English
Access Restriction	Open
Subject Keyword	Archaea Chromosomes DNA Replication Gene Duplication Abnormality Region of chromosome Replication Origin rfcS protein, Pyrococcus furiosus
Content Type	Text
Resource Type	Article

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