NDLI: Development of novel multifunction directly compressible co-processed excipient by melt granulation technique

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Development of novel multifunction directly compressible co-processed excipient by melt granulation technique

Content Provider	Semantic Scholar
Author	Garg, Nidhi Pandey, Parijat Kaushik, Deepak Kumar Dureja, Harish
Copyright Year	2015
Abstract	INTRODUCTION The objective of the present investigation was to develop a novel multifunctional directly compressible co-processed excipient consisting of dibasic calcium phosphate anhydrous, polyethylene glycol 4000 (PEG 4000) and crospovidone using Box-Behnken design. MATERIALS AND METHODS The technique of melt granulation was adopted for the preparation of the co-processed excipient. The percentage of crospovidone (5-10% w/w), percentage of PEG 4000 (5-15% w/w) and the heating time (4-12 min) were selected as independent variables. The co-processed granules were evaluated for bulk density, tapped density, Hausner's ratio and Carr's index. Placebo tablets of co-processed granules were prepared and evaluated for hardness, friability and disintegration time. Multiple linear regression was applied to develop mathematical models for hardness, Carr' index and disintegrating time. ANOVA was applied to study the fitting and significance of the model. The optimized batches (BB) were selected for further studies. The selected batches were characterized for particle size distribution, granular friability index, moisture uptake study, differential scanning calorimetry, Fourier transform infrared spectroscopy and scanning electron microscopy. Aceclofenac was selected as model drug for the preparation of tablets. RESULTS Aceclofenac tablets prepared using co-processed excipients showed better hardness, disintegration time and in vitro drug release as compared to aceclofenac tablets prepared using conventional wet granulation method. CONCLUSION The developed co-processed excipient can serve as a novel co-processed excipient for improvement of tableting characteristics.
Starting Page	266
Ending Page	274
Page Count	9
File Format	PDF HTM / HTML
DOI	10.4103/2230-973X.167692
PubMed reference number	26682197
Journal	Medline
Volume Number	5
Alternate Webpage(s)	http://s9423e139345e2186.jimcontent.com/download/version/1445925735/module/10106590298/name/PharmInvestigations54266-720305_020003.pdf
Alternate Webpage(s)	https://doi.org/10.4103/2230-973X.167692
Journal	International journal of pharmaceutical investigation
Language	English
Access Restriction	Open
Content Type	Text
Resource Type	Article

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