NDLI: Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.

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Phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3)/Tec kinase-dependent calcium signaling pathway: a target for SHIP-mediated inhibitory signals.

Content Provider	Semantic Scholar
Author	Scharenberg, Andrew M. El-Hillal, O. Fruman, David A. Beitz, Laurie O. Li, Zaibo Lin, Sheng-Cai Gout, Ivan Rawlings, David J. Kinét, J. P.
Copyright Year	1998
Abstract	Tec family non-receptor tyrosine kinases have been implicated in signal transduction events initiated by cell surface receptors from a broad range of cell types, including an essential role in B-cell development. A unique feature of several Tec members among known tyrosine kinases is the presence of an N-terminal pleckstrin homology (PH) domain. We directly demonstrate that phosphatidylinositol-3,4,5-trisphosphate (PtdIns-3,4,5-P3) interacting with the PH domain acts as an upstream activation signal for Tec kinases, resulting in Tec kinase-dependent phospholipase Cgamma (PLCgamma) tyrosine phosphorylation and inositol trisphosphate production. In addition, we show that this pathway is blocked when an SH2-containing inositol phosphatase (SHIP)-dependent inhibitory receptor is engaged. Together, our results suggest a general mechanism whereby PtdIns-3,4,5-P3 regulates receptor-dependent calcium signals through the function of Tec kinases.
File Format	PDF HTM / HTML
Alternate Webpage(s)	http://emboj.embopress.org/content/embojnl/17/7/1961.full.pdf
PubMed reference number	9524119v1
Volume Number	17
Issue Number	7
Journal	The EMBO journal
Language	English
Access Restriction	Open
Subject Keyword	Calcium Signaling Cell development Chronic Lymphocytic Leukemia Homologous Gene INPP5D gene Phospholipase C gamma Pleckstrin Homology Domains Protein Tyrosine Phosphatase Receptor Protein-Tyrosine Kinases Signal Transduction TEC Protein Tyrosine Kinase Tyrosine Phosphorylation negative regulation of inositol biosynthetic process negative regulation of phospholipase C-activating G-protein coupled receptor signaling pathway
Content Type	Text
Resource Type	Article

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