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Impact of wall thickness and saccular geometry on the computational wall stress of descending thoracic aortic aneurysms.
| Content Provider | Semantic Scholar |
|---|---|
| Author | Shang, Eric K. Nathan, Derek P. Sprinkle, Shanna R. Fairman, Ronald M. Bavaria, Joseph E. Gorman, Robert C. Gorman, Joseph H. Jackson, Benjamin M. |
| Copyright Year | 2013 |
| Abstract | BACKGROUND Wall stress calculated using finite element analysis has been used to predict rupture risk of aortic aneurysms. Prior models often assume uniform aortic wall thickness and fusiform geometry. We examined the effects of including local wall thickness, intraluminal thrombus, calcifications, and saccular geometry on peak wall stress (PWS) in finite element analysis of descending thoracic aortic aneurysms. METHODS AND RESULTS Computed tomographic angiography of descending thoracic aortic aneurysms (n=10 total, 5 fusiform and 5 saccular) underwent 3-dimensional reconstruction with custom algorithms. For each aneurysm, an initial model was constructed with uniform wall thickness. Experimental models explored the addition of variable wall thickness, calcifications, and intraluminal thrombus. Each model was loaded with 120 mm Hg pressure, and von Mises PWS was computed. The mean PWS of uniform wall thickness models was 410 ± 111 kPa. The imposition of variable wall thickness increased PWS (481 ± 126 kPa, P<0.001). Although the addition of calcifications was not statistically significant (506 ± 126 kPa, P=0.07), the addition of intraluminal thrombus to variable wall thickness (359 ± 86 kPa, P ≤ 0.001) reduced PWS. A final model incorporating all features also reduced PWS (368 ± 88 kPa, P<0.001). Saccular geometry did not increase diameter-normalized stress in the final model (77 ± 7 versus 67 ± 12 kPa/cm, P=0.22). CONCLUSIONS Incorporation of local wall thickness can significantly increase PWS in finite element analysis models of thoracic aortic aneurysms. Incorporating variable wall thickness, intraluminal thrombus, and calcifications significantly impacts computed PWS of thoracic aneurysms; sophisticated models may, therefore, be more accurate in assessing rupture risk. Saccular aneurysms did not demonstrate a significantly higher normalized PWS than fusiform aneurysms. |
| Starting Page | 147 |
| Ending Page | 152 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/128/11_suppl_1/S157.full.pdf |
| Alternate Webpage(s) | http://circ.ahajournals.org/content/circulationaha/128/11_suppl_1/S157.full.pdf?download=true |
| PubMed reference number | 24030401v1 |
| Alternate Webpage(s) | https://doi.org/10.1161/CIRCULATIONAHA.112.000200 |
| DOI | 10.1161/CIRCULATIONAHA.112.000200 |
| Journal | Circulation |
| Volume Number | 128 |
| Issue Number | 11 |
| Language | English |
| Access Restriction | Open |
| Subject Keyword | Aortic Aneurysm Aortic Aneurysm, Thoracic Blood Clot Chest Diameter (qualifier value) Dissecting aneurysm of the thoracic aorta Finite Element Analysis Fusiform Aneurysm Intracranial Aneurysm Kilopascal Mercury Partial Wave Spectroscopic Microscopy Physiologic calcification Rupture Thrombosis algorithm angiogram |
| Content Type | Text |
| Resource Type | Article |
