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Assessing spinal muscular atrophy with quantitative ultrasound
| Content Provider | Scilit |
|---|---|
| Author | Wu, Jim S. Darras, Basil T. Rutkove, Seward B. |
| Copyright Year | 2010 |
| Description | Journal: Neurology Objective: To assess the value of quantitative ultrasound in patients with type 2 and 3 spinal muscular atrophy (SMA). Methods: Twenty-five patients with SMA (15 type 2 and 10 type 3) and 21 normal subjects were enrolled for this observational study. Strength of biceps brachii, wrist extensors, quadriceps, and tibialis anterior were measured with hand-held dynamometry. In addition, these 4 muscles were studied with a standard ultrasound system using a 5-MHz probe, and luminosity values for each muscle and the overlying subcutaneous fat were obtained by subsequent image analysis. A luminosity ratio (LR) for each muscle was calculated by dividing the muscle by the subcutaneous fat luminosity. The LR and strength scores for all 4 muscles were averaged to provide a single summary value for each patient. Results: The LRs increased with disease severity: 1.27 ± 0.26 for normal subjects, 2.43 ± 0.78 for type 3 SMA, and 3.85 ± 1.3 for type 2 SMA (p < 0.001). Taking all the normal subject and patient data together, there was a good correlation between strength and LR (r = −0.711, p < 0.001). There was also a moderate relationship between LR and strength in the patients with SMA alone (r = −0.588, p = 0.008), and, as expected, a nonsignificant relationship between LR and strength in normal subjects (r = −0.011). Conclusions: Quantitative ultrasound has the potential of serving as a marker of SMA severity and may be useful in future clinical trials. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2918474/pdf http://n.neurology.org/content/75/6/526.full.pdf |
| Ending Page | 531 |
| Page Count | 6 |
| Starting Page | 526 |
| e-ISSN | 1526632X |
| DOI | 10.1212/WNL.0b013e3181eccf8f |
| Journal | Neurology |
| Issue Number | 6 |
| Volume Number | 75 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2010-08-09 |
| Access Restriction | Open |
| Subject Keyword | Journal: Neurology Quantitative Ultrasound Spinal Muscular Atrophy |
| Content Type | Text |
| Resource Type | Article |
