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APOE- 4 is associated with memory decline in cognitively impaired elderly
| Content Provider | Scilit |
|---|---|
| Author | Dik, M. G. Jonker, C. Bouter, Lex Geerlings, M. I. Kamp, G. J. Van Deeg, D. J. H. |
| Copyright Year | 2000 |
| Description | Journal: Neurology To investigate whether the association between APOE-epsilon4 and memory decline is modified by baseline cognition and age in a population-based elderly sample. The study sample consisted of 1,243 subjects, 62 to 85 years old, with a Mini-Mental State Examination (MMSE) score between 21 and 30 and known APOE phenotypes. Memory performance was measured with an abbreviated Auditory Verbal Learning Test (AVLT) at baseline and repeated after 3 years (n = 854). Memory decline was defined as a decrease of at least 1 SD from the mean change score on immediate recall (IR), delayed recall (DR), and retention, based on the AVLT. Multivariate logistic regression analyses showed that APOE-epsilon4 is associated with memory decline in cognitively impaired subjects (MMSE score, 21 to 26) (OR for decline on IR adjusted for age, sex, education, and baseline recall score, 3.8; 95% CI, 1.4 to 10.0; adjusted OR for decline on DR, 2.9; 95% CI, 1.2 to 7.0; adjusted OR for decline on retention, 3.3; 95% CI, 1.1 to 10. 1), but not in cognitively normal subjects (MMSE score, 27 to 30) (adjusted OR for decline on IR, 1.1; 95% CI, 0.6 to 2.0; adjusted OR for decline on DR, 1.0; 95% CI, 0.6 to 1.8; adjusted OR for decline on retention, 1.5; 95% CI, 0.7 to 3.0). In particular, cognitively impaired epsilon4 carriers older than 75 years were at high risk of memory decline (adjusted OR for decline on IR, 4.5; 95% CI, 1.4 to 13.8; adjusted OR for decline on DR, 3.6; 95% CI, 1.2 to 10.8; adjusted OR for decline on retention, 6.6; 95% CI, 1.5 to 29.7). APOE-epsilon4 was associated with memory decline in subjects with cognitive impairment, but not in normally functioning subjects. Contrary to AD studies, our study suggests that the risk of APOE-epsilon4 on memory decline does not decrease at higher ages. |
| Related Links | https://research.vu.nl/ws/files/1879568/155536.PDF |
| Ending Page | 1497 |
| Page Count | 6 |
| Starting Page | 1492 |
| e-ISSN | 1526632X |
| DOI | 10.1212/wnl.54.7.1492 |
| Journal | Neurology |
| Issue Number | 7 |
| Volume Number | 54 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2000-04-11 |
| Access Restriction | Open |
| Subject Keyword | Journal: Neurology Memory Decline Cognitively Impaired Apoe Epsilon4 |
| Content Type | Text |
| Resource Type | Article |
