NDLI: G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease

Please wait, while we are loading the content...

G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease

Content Provider	Scilit
Author	Belmonte, Stephen L. Blaxall, Burns C.
Copyright Year	2011
Description	Journal: Circulation Research G protein-coupled receptors (GPCRs) represent the largest family of membrane receptors and are responsible for regulating a wide variety of physiological processes. This is accomplished via ligand binding to GPCRs, activating associated heterotrimeric G proteins and intracellular signaling pathways. G protein-coupled receptor kinases (GRKs), in concert with β-arrestins, classically desensitize receptor signal transduction, thus preventing hyperactivation of GPCR second-messenger cascades. As changes in GRK expression have featured prominently in many cardiovascular pathologies, including heart failure, myocardial infarction, hypertension, and cardiac hypertrophy, GRKs have been intensively studied as potential diagnostic or therapeutic targets. Herein, we review our evolving understanding of the role of GRKs in cardiovascular pathophysiology.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146028/pdf https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.110.231233
Ending Page	319
Page Count	11
Starting Page	309
ISSN	00097330
e-ISSN	15244571
DOI	10.1161/circresaha.110.231233
Journal	Circulation Research
Issue Number	3
Volume Number	109
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2011-07-22
Access Restriction	Open
Subject Keyword	Journal: Circulation Research Peripheral Vascular Disease G Protein-coupled Receptors G Protein-coupled Receptor Kinases Cardiovascular Disease Heart Failure Adrenergic Receptors
Content Type	Text
Resource Type	Article
Subject	Physiology Cardiology and Cardiovascular Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

G$ _{i}$ -Biased β$ _{2}$ AR Signaling Links GRK2 Upregulation to Heart Failure

Differential Role of G Protein–Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy

Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy

G-protein coupled receptor kinases (GRKs) as Therapeutic Targets in Cardiovascular Disease

Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction

GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure

Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure

β2-Adrenergic Receptor Signaling in the Cardiac Myocyte is Modulated by Interactions With CXCR4

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease

Similar Documents

G$ _{i}$ -Biased β$ _{2}$ AR Signaling Links GRK2 Upregulation to Heart Failure

Differential Role of G Protein–Coupled Receptor Kinase 5 in Physiological Versus Pathological Cardiac Hypertrophy

Determining the Absolute Requirement of G Protein–Coupled Receptor Kinase 5 for Pathological Cardiac Hypertrophy

G-protein coupled receptor kinases (GRKs) as Therapeutic Targets in Cardiovascular Disease

Leveraging Signaling Pathways to Treat Heart Failure With Reduced Ejection Fraction

GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure

Prognostic Value of Lymphocyte G Protein-Coupled Receptor Kinase-2 Protein Levels in Patients With Heart Failure

β2-Adrenergic Receptor Signaling in the Cardiac Myocyte is Modulated by Interactions With CXCR4

G Protein–Coupled Receptor Kinase 2 Ablation in Cardiac Myocytes Before or After Myocardial Infarction Prevents Heart Failure

G Protein Coupled Receptor Kinases as Therapeutic Targets in Cardiovascular Disease