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Late Gadolinium Enhancement on Cardiac Magnetic Resonance Predicts Adverse Cardiovascular Outcomes in Nonischemic Cardiomyopathy
| Content Provider | Scilit |
|---|---|
| Author | Kuruvilla, Sujith Adenaw, Nebiyu Katwal, Arabindra B. Lipinski, Michael J. Kramer, Christopher M. Salerno, Michael |
| Copyright Year | 2014 |
| Description | Journal: Circulation: Cardiovascular Imaging Background—: Late gadolinium enhancement (LGE) by cardiac MR (CMR) is a predictor of adverse cardiovascular outcomes in patients with nonischemic cardiomyopathy (NICM). However, these findings are limited by single-center studies, small sample sizes, and low event rates. We performed a meta-analysis to evaluate the prognostic role of LGE by CMR (LGE-CMR) imaging in patients with NICM. Methods and Results—: PubMed, Cochrane CENTRAL, and EMBASE were searched for studies looking at the prognostic value of LGE-CMR in patients with NICM. The primary end points included all-cause mortality, heart failure hospitalization, and a composite end point of sudden cardiac death (SCD) or aborted SCD. Pooling of odds ratios was performed using a random-effect model, and annualized event rates were assessed. Data were included from 9 studies with a total of 1488 patients and a mean follow-up of 30 months. Patients had a mean age of 52 years, 67% were men, and the average left ventricular ejection fraction was 37% on CMR. LGE was present in 38% of patients. Patients with LGE had increased overall mortality (odds ratio, 3.27; P <0.00001), heart failure hospitalization (odds ratio, 2.91; P =0.02), and SCD/aborted SCD (odds ratio, 5.32; P <0.00001) compared with those without LGE. The annualized event rates for mortality were 4.7% for LGE+ subjects versus 1.7% for LGE− subjects ( P =0.01), 5.03% versus 1.8% for heart failure hospitalization ( P =0.002), and 6.0% versus 1.2% for SCD/aborted SCD ( P <0.001). Conclusions—: LGE in patients with NICM is associated with increased risk of all-cause mortality, heart failure hospitalization, and SCD. Detection of LGE by CMR has excellent prognostic characteristics and may help guide risk stratification and management in patients with NICM. |
| Related Links | https://www.ahajournals.org/doi/pdf/10.1161/CIRCIMAGING.113.001144 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4007583/pdf https://www.ahajournals.org/doi/reader/10.1161/CIRCIMAGING.113.001144 |
| Ending Page | 258 |
| Page Count | 9 |
| Starting Page | 250 |
| ISSN | 19419651 |
| e-ISSN | 19420080 |
| DOI | 10.1161/circimaging.113.001144 |
| Journal | Circulation: Cardiovascular Imaging |
| Issue Number | 2 |
| Volume Number | 7 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2014-03-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Circulation: Cardiovascular Imaging Peripheral Vascular Disease Late Gadolinium Enhancement Nonischemic Cardiomiopathy Cardiac Magnetic Resonance Imaging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Cardiology and Cardiovascular Medicine |
