The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans

Content Provider	Scilit
Author	Ribeiro, Luciana Busnello, João V. Cantor, Rita M. Whelan, Fiona Whittaker, Pamela Deloukas, Panos Wong, Ma-Li Licinio, Julio
Copyright Year	2007
Description	Journal: NeuroReport The hypothesis that brain-derived neurotrophic factor (BDNF) is involved in the pathogenesis of major depression is supported by several research findings; however, genetic studies assessing the relationship between BDNF and psychiatric disorders have produced conflicting results. We examined the effect of a BDNF polymorphism on depression susceptibility in Mexican-Americans. The single nucleotide polymorphism (Val66Met), which has been shown to have functional and behavioral effects, was genotyped in 284 depressed participants and 331 controls, showing association with depression (P=0.005). Individuals homozygous for the major allele (GG) had an increased chance of being depressed (OR=1.7 95% CI 1.17–2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans.
Related Links	http://europepmc.org/articles/pmc2686836?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2686836/pdf
Ending Page	1293
Page Count	3
Starting Page	1291
ISSN	09594965
e-ISSN	1473558X
DOI	10.1097/wnr.0b013e328273bcb0
Journal	NeuroReport
Issue Number	12
Volume Number	18
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2007-08-06
Access Restriction	Open
Subject Keyword	Journal: NeuroReport Biological Psychology Bdnf (brain Derived Neurotrophic Factor), Major Depressive Disorder, Mexican-americans, Pharmacogenetics, Polymorphism, Psychiatry, Single Nucleotide Polymorphism, Rs6265, Val66met
Content Type	Text
Resource Type	Article
Subject	Neuroscience