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Nebulized hypertonic saline attenuates acute lung injury following trauma and hemorrhagic shock via inhibition of matrix metalloproteinase-13*
| Content Provider | Scilit |
|---|---|
| Author | Wohlauer, Max V. Moore, Ernest E. Silliman, Christopher C. Fragoso, Miguel Gamboni, Fabia Harr, Jeffrey Accurso, Frank J. Wright, Franklin Haenel, James B. Fullerton, David A. Banerjee, Anirban |
| Copyright Year | 2012 |
| Description | Journal: Critical Care Medicine Objective: We hypothesized that aerosolized inhaled hypertonic saline given at the onset of resuscitation will decrease acute lung injury following hemorrhagic shock, by inhibiting the release of epithelial derived proinflammatory mediators. Design: Animal study. Setting: Animal-care facility procedure room in a medical center. Subjects: Adult male Sprague-Dawley rats. Interventions: Rats underwent hemorrhagic shock followed by 2 hrs of resuscitation and 1 hr of observation. In the study group, nebulized hypertonic saline was delivered at the end of the shock period and after 1 hr and 2 hrs of resuscitation. Measurements and Main Results: Shock provoked acute lung injury, which was attenuated with inhaled hypertonic saline (1.56 ± 0.2 mg protein/mL vs. 0.95 ± 0.3 mg protein/mL bronchoalveolar lavage fluid, shock vs. shock + hypertonic saline, p < .01). Nebulized hypertonic saline reduced inflammation (cytokine-induced neutrophil chemoattractant-1 accumulation in bronchoalveolar lavage fluid 5999 ± 1267 pg/mL vs. 3342 ± 859 pg/mL, shock vs. shock + hypertonic saline, p = .006). Additionally, nebulized hypertonic saline inhibited matrix metalloproteinase-13 accumulation in the bronchoalveolar lavage fluid (1513 ± 337 pg/mL bronchoalveolar lavage fluid vs. 230 ± 19 pg/mL, shock vs. shock + hypertonic saline, p = .009) and pretreatment with a matrix metalloproteinase-13 inhibitor was sufficient to attenuate postshock acute lung injury (1.42 ± 0.09 mg/mL vs. 0.77 ± 0.23 mg/mL bronchoalveolar lavage protein, shock vs. shock + matrix metalloproteinase-13 inhibitor CL-82198, p = .002). Conclusion: Inhaled hypertonic saline attenuates postshock acute lung injury by exerting an anti-inflammatory effect on the pulmonary epithelium, suggesting a new clinical strategy to treat acute lung injury/acute respiratory distress syndrome. |
| Related Links | http://europepmc.org/articles/pmc3519396?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3519396/pdf |
| Ending Page | 2653 |
| Page Count | 7 |
| Starting Page | 2647 |
| ISSN | 00903493 |
| e-ISSN | 15300293 |
| DOI | 10.1097/ccm.0b013e3182592006 |
| Journal | Critical Care Medicine |
| Issue Number | 9 |
| Volume Number | 40 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2012-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Critical Care Medicine Critical Care Medicine Acute Lung Injury Acute Respiratory Distress Syndrome Hemorrhagic Shock Hypertonic Saline |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine |
