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Mechanisms of lung ischemia-reperfusion injury
| Content Provider | Scilit |
|---|---|
| Author | Laubach, Victor E. Sharma, Ashish K. |
| Copyright Year | 2016 |
| Description | Journal: Current Opinion in Organ Transplantation Lungs are extremely susceptible to injury, and despite advances in surgical management and immunosuppression, outcomes for lung transplantation are the worst of any solid organ transplant. The success of lung transplantation is limited by high rates of primary graft dysfunction because of ischemia-reperfusion injury characterized by robust inflammation, alveolar damage, and vascular permeability. This review will summarize major mechanisms of lung ischemia-reperfusion injury with a focus on the most recent findings in this area. Over the past 18 months, numerous studies have described strategies to limit lung ischemia-reperfusion injury in experimental settings, which often reveal mechanistic insight. Many of these strategies involved the use of various antioxidants, anti-inflammatory agents, mesenchymal stem cells, and ventilation with gaseous molecules. Further advancements have been achieved in understanding mechanisms of innate immune cell activation, neutrophil infiltration, endothelial barrier dysfunction, and oxidative stress responses. Methods for prevention of primary graft dysfunction after lung transplant are urgently needed, and understanding mechanisms of ischemia-reperfusion injury is critical for the development of novel and effective therapeutic approaches. In doing so, both acute and chronic outcomes of lung transplant recipients will be significantly improved. |
| Related Links | http://europepmc.org/articles/pmc4861054?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4861054/pdf |
| Ending Page | 252 |
| Page Count | 7 |
| Starting Page | 246 |
| ISSN | 10872418 |
| e-ISSN | 15317013 |
| DOI | 10.1097/mot.0000000000000304 |
| Journal | Current Opinion in Organ Transplantation |
| Issue Number | 3 |
| Volume Number | 21 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2016-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Current Opinion in Organ Transplantation Respiratory System Lung Transplantation Ischemia-reperfusion Injury Primary Graft Dysfunction |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Transplantation |
