A Prospective Study of Cardiorespiratory Fitness and Breast Cancer Mortality

Content Provider	Scilit
Author	Peel, J. Brent Sui, Xuemei Adams, Swann A. Hébert, James R. Hardin, James W. Blair, Steven N.
Copyright Year	2009
Description	Journal: Medicine & Science In Sports & Exercise Purpose: Physical activity may protect against breast cancer. Few prospective studies have evaluated breast cancer mortality in relation to cardiorespiratory fitness (CRF), an objective marker of physiologic response to physical activity habits. Methods: We examined the association between CRF and risk of death from breast cancer in the Aerobics Center Longitudinal Study. Women (N = 14,811), aged 20 to 83 yr with no prior breast cancer history, received a preventive medical examination at the Cooper Clinic in Dallas, Texas, between 1970 and 2001. Mortality surveillance was completed through December 31, 2003. CRF was quantified as maximal treadmill exercise test duration and was categorized for analysis as low (lowest 20% of exercise duration), moderate (middle 40%), and high (upper 40%). At baseline, all participants were able to complete the exercise test to at least 85% of their age-predicted maximal heart rate. Results: A total of 68 breast cancer deaths occurred during follow-up (mean = 16 yr). Age-adjusted breast cancer mortality rates per 10,000 woman-years were 4.4, 3.2, and 1.8 for low, moderate, and high CRF groups, respectively (trend P = 0.008). After further controlling for body mass index, smoking, drinking, chronic conditions, abnormal exercise ECG responses, family history of breast cancer, oral contraceptive use, and estrogen use, hazard ratios (95% CI) for breast cancer mortality across incremental CRF categories were 1.00 (referent), 0.67 (0.35-1.26), and 0.45 (0.22-0.95) (trend P = 0.04). Conclusions: These results indicate that CRF is associated with a reduced risk of dying from breast cancer in women.
Related Links	http://europepmc.org/articles/pmc3774121?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3774121/pdf
Ending Page	748
Page Count	7
Starting Page	742
ISSN	01959131
e-ISSN	15300315
DOI	10.1249/mss.0b013e31818edac7
Journal	Medicine & Science In Sports & Exercise
Issue Number	4
Volume Number	41
Language	English
Publisher	Ovid Technologies (Wolters Kluwer Health)
Publisher Date	2009-04-01
Access Restriction	Open
Subject Keyword	Journal: Medicine & Science In Sports & Exercise Nutrition and Dietetics Death From Breast Cancer Physical Activity
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine Physical Therapy, Sports Therapy and Rehabilitation Sports Science