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Sensitive Cardiac Troponin T Assay and the Risk of Incident Cardiovascular Disease in Women With and Without Diabetes Mellitus
| Content Provider | Scilit |
|---|---|
| Author | Everett, Brendan M. Cook, Nancy R. Magnone, Maria C. Bobadilla, Maria Kim, Eunjung Rifai, Nader Ridker, Paul M. Pradhan, Aruna D. |
| Copyright Year | 2011 |
| Description | Journal: Circulation Background—: Very low levels of cardiac troponin T are associated with an increased risk of cardiovascular death in patients with stable chronic coronary disease. Whether high-sensitivity cardiac troponin T levels are associated with adverse cardiovascular outcomes in individuals without cardiovascular disease (CVD) has not been well studied. Methods and Results—: Using 2 complementary study designs, we evaluated the relationship between baseline cardiac troponin and incident CVD events among diabetic and nondiabetic participants in the Women's Health Study (median follow-up, 12.3 years). All diabetic women with blood specimens were included in a cohort study (n=512 diabetic women, n=65 events), and nondiabetic women were sampled for inclusion in a case-cohort analysis (n=564 comprising the subcohort, n=479 events). High-sensitivity cardiac troponin T was detectable (≥0.003 μg/L) in 45.5% of diabetic women and 30.3% of nondiabetic women ( P <0.0001). In models adjusted for traditional risk factors and hemoglobin A$ _{1c}$ , detectable high-sensitivity cardiac troponin T was associated with subsequent CVD (myocardial infarction, stroke, cardiovascular death) in diabetic women (adjusted hazard ratio, 1.79; 95% confidence interval, 1.04 to 3.07, P =0.036) but not nondiabetic women (adjusted hazard ratio, 1.13; 95% confidence interval, 0.82 to 1.55; P =0.46). Further adjustment for amino-terminal pro-B-type natriuretic peptide and estimated renal function did not substantially alter this relationship among diabetic women (hazard ratio, 1.76; 95% confidence interval, 1.00 to 3.08; P =0.0499), which appeared to be driven by a 3-fold increase in CVD death that was not observed in nondiabetic women. Conclusions—: Very low but detectable levels of cardiac troponin T are associated with total CVD and CVD death in women with diabetes mellitus. Among healthy nondiabetic women, detectable compared with undetectable troponin was not associated with CVD events. |
| Related Links | https://www.ahajournals.org/doi/pdf/10.1161/CIRCULATIONAHA.110.009928 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144564/pdf https://www.ahajournals.org/doi/reader/10.1161/CIRCULATIONAHA.110.009928 |
| Ending Page | 2818 |
| Page Count | 8 |
| Starting Page | 2811 |
| ISSN | 00097322 |
| e-ISSN | 15244539 |
| DOI | 10.1161/circulationaha.110.009928 |
| Journal | Circulation |
| Issue Number | 24 |
| Volume Number | 123 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2011-06-21 |
| Access Restriction | Open |
| Subject Keyword | Journal: Circulation Peripheral Vascular Disease Risk Factors Cardiovascular Diseases Diabetes Mellitus, Type 2 Primary Prevention |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology (medical) Cardiology and Cardiovascular Medicine |
