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Redox Stress Defines the Small Artery Vasculopathy of Hypertension
| Content Provider | Scilit |
|---|---|
| Author | Touyz, Rhian M. Montezano, Augusto C. Rios, Francisco Widlansky, Michael E. Liang, Mingyu |
| Copyright Year | 2017 |
| Description | Journal: Circulation Research While convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not translated to the clinic. We discuss this bench-to-bedside disparity and the urgency to progress vascular redox pathobiology from experimental models to patients by studying disease-relevant human tissues. It is only through such approaches that the unambiguous role of vascular redox stress will be defined so that mechanism-based therapies in a personalized and precise manner can be developed to prevent, slow or reverse progression of small vessel disorders and consequent hypertension. |
| Related Links | http://europepmc.org/articles/pmc5520661?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5520661/pdf https://www.ahajournals.org/doi/pdf/10.1161/CIRCRESAHA.117.310672 |
| Ending Page | 1723 |
| Page Count | 3 |
| Starting Page | 1721 |
| ISSN | 00097330 |
| e-ISSN | 15244571 |
| DOI | 10.1161/circresaha.117.310672 |
| Journal | Circulation Research |
| Issue Number | 11 |
| Volume Number | 120 |
| Language | English |
| Publisher | Ovid Technologies (Wolters Kluwer Health) |
| Publisher Date | 2017-05-26 |
| Access Restriction | Open |
| Subject Keyword | Journal: Circulation Research Peripheral Vascular Disease Cardiovascular Diseases |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Cardiology and Cardiovascular Medicine |
